MEMO1 Antibody
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中文名稱：MEMO1兔多克隆抗體
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貨號：CSB-PA013693GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：MEMO1
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別名：C21orf19-like protein antibody; C2orf4 antibody; CGI 27 antibody; DKFZp434I0135 antibody; FLJ25031 antibody; HCV NS5A-transactivated protein 7 antibody; Hepatitis C virus NS5A-transactivated protein 7 antibody; Mediator of cell motility 1 antibody; Mediator of ErbB2-driven cell motility 1 antibody; MEMO antibody; Memo-1 antibody; memo1 antibody; MEMO1_HUMAN antibody; NS5ATP7 antibody; Protein MEMO1 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human MEMO1
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.
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基因功能參考文獻：
- Study identify Memo as an important key mediator between the heregulin and estrogen signaling pathways, which affects both breast cancer cell migration and proliferation. PMID: 27472465
- HRG/HER2/HER3 signaling promotes AhR-mediated Memo-1 expression and migration in colorectal cancer PMID: 27941874
- Biochemical assays revealed that Memo is a copper-dependent redox enzyme that promoted a more oxidized intracellular milieu and stimulated the production of reactive oxygen species (ROS) in cellular structures involved in migration. PMID: 24917593
- Mediator of ERBB2-driven cell motility (MEMO) promotes extranuclear estrogen receptor signaling involving the growth factor receptors IGF1R and ERBB2. PMID: 23861392
- MEMO1 is involved in breast carcinogenesis via regulating insulin-like growth factor-I receptor-dependent signaling events. PMID: 22824790
- data suggest that Memo controls cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton [Memo] PMID: 15156151
- 2.1A crystal structure and homology to class III nonheme iron-dependent dioxygenases PMID: 18045866
- Memo-RhoA-mDia1 signaling coordinates the organization of the lamellipodial actin network, adhesion site formation, and microtubule outgrowth within the cell leading edge to sustain cell motility. PMID: 18955552
- Memo was detected in complexes with cofilin, ErbB2 and PLCgamma1. PMID: 19223396
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蛋白家族：MEMO1 family
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