MED28 Antibody, HRP conjugated
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中文名稱：MED28兔多克隆抗體, HRP偶聯(lián)
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貨號(hào)：CSB-PA863955LB01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) MED28 Polyclonal antibody
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Uniprot No.：
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基因名：MED28
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別名：EG1 antibody; Endothelial-derived protein 1 antibody; FKSG20 antibody; Magicin antibody; med28 antibody; MED28_HUMAN antibody; Mediator complex subunit 28 antibody; Mediator of RNA polymerase II transcription subunit 28 antibody; Merlin and Grb2-interacting cytoskeletal protein antibody; Tumor angiogenesis marker EG-1 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Mediator of RNA polymerase II transcription subunit 28 protein (1-178AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點(diǎn)詳情
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功能：Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways.
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基因功能參考文獻(xiàn)：
- MED28 modulates the development of epithelial-mesenchymal transition through NFkappaB in human breast cancer cells. PMID: 27662245
- All trans-retinoic acid can reverse the suppressive effect of MED28 on HBP1 and E-cadherin and inactivate the Wnt/beta-catenin pathway in colorectal cancer, suggesting a protective effect of ATRA against colorectal cancer. PMID: 26660958
- This paper describes a link between Med23 and IFN-lambda3, provides evidence for the crucial role of IFN-lambda in HSV-1 immune control. PMID: 23950709
- These data indicate that MED28 regulates cellular migration in a MEK1-dependent manner in human breast cancer cells, reinforcing the important cellular roles of MED28. PMID: 22495818
- High MED28 is associated with breast cancer. PMID: 20584319
- demonstrate an interaction between Grb2 and magicin. In addition, merlin is capable of forming a ternary complex with magicin and Grb2 PMID: 15467741
- EG-1 is a positive stimulator of cellular proliferation, and may possibly be involved in signaling pathways involving Src and MAPK activation. PMID: 16024617
- May serve as a multi-faceted adaptor/scaffold to relay cellular signaling to the cytoskeleton and from the cytoskeleton to the nucleus. PMID: 16899217
- EG-1 may be involved in signaling pathways including c-Src activation. PMID: 16964398
- EG-1 has a role in breast tumor growth PMID: 17568184
- Study reports that down-regulation of human Med28 expression in NIH3T3 cells results in a significant induction of several genes associated with smooth muscle cell (SMC)differentiation; conversely, overexpression of MED28 represses SMC gene expression. PMID: 17848560
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亞細(xì)胞定位：Nucleus. Cytoplasm. Membrane; Peripheral membrane protein. Note=According to PubMed:15467741, it is cytoplasmic and mainly membrane-associated.
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蛋白家族：Mediator complex subunit 28 family
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組織特異性：Widely expressed. Highly expressed in vascular tissues such as placenta, testis and liver.
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數(shù)據(jù)庫(kù)鏈接：
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