MED19 Antibody
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中文名稱(chēng)：MED19兔多克隆抗體
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貨號(hào)：CSB-PA013652GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：MED19
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別名：LCMR1 antibody; Lung cancer metastasis related protein 1 antibody; Lung cancer metastasis-related protein 1 antibody; med19 antibody; MED19_HUMAN antibody; Mediator complex subunit 19 antibody; Mediator of RNA polymerase II transcription subunit 19 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Human MED19
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
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靶點(diǎn)詳情
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功能：Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
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基因功能參考文獻(xiàn)：
- The data suggest that Med19 expression correlates with aggressive characteristics of bladder cancer, and Med19 knockdown suppresses the proliferation and migration of cancer cells through down-regulating the Wnt/beta-catenin pathway. PMID: 28631286
- DEK and LCMR1 were demonstrated to cooperate in the inhibition of apoptosis in lung cancer cells. PMID: 28765911
- LCMR1 modulation was sufficient to positively regulate endogenous Tspan8 expression, with concomitant in vitro phenotypic changes such as loss of melanoma cell-matrix adherence and increase in invasion, and Tspan8 expression promoted tumourigenicity in vivo. PMID: 27375018
- We knocked down the Med19 expression in prostate cancer cell lines LNCaP and PC3 by using lentivirus siRNA. Cell proliferation, anchor-independent growth, migration, and invasion were suppressed in Med19 knockdown prostate cancer cells. PMID: 28125713
- Med19 promotes breast cancer cell proliferation and that this effect is associated with regulating CBFA2T3 and HEB expression. PMID: 27572702
- FOXD3/miR-214/MED19 axis is important for the regulation of growth, invasion and metastasis of colorectal cancer PMID: 27811858
- High expression of Med19 is associated with cisplatin resistance in non-small cell lung cancer cells. PMID: 25735376
- Data show that the expression of Mediator of RNA polymerase II transcription subunit 19 (Med19) was increased in Osteosarcoma (OS) samples from patients compared to normal bone tissues. PMID: 24565852
- High Med19 expression is associated with tongue cancer. PMID: 23705783
- Med19 promotes bone metastasis and invasiveness of bladder urothelial carcinoma via bone morphogenetic protein 2. PMID: 23276457
- Med19 is markedly up-regulated in bladder cancer tissues PMID: 21478038
- LCMR1 suppresses apoptosis in lung cancer cells and this effect is associated with multiple apoptosis-related proteins, including p53, Bax and Mcl-1. PMID: 23076562
- High MED19 expression is associated with lung adenocarcinoma cell clone conformation, growth, and metastasis. PMID: 23098456
- Med19 functions in promoting cellular growth and may be a useful therapeutic target in malignant gastric carcinoma PMID: 22565189
- The effect of downregulation of LCMR1 by lentivirus-mediated small hairpin RNA (shRNA) on colorectal cancer cell proliferation and tumorigenesis was explored. PMID: 21732059
- MED19 serves as a novel proliferation regulator that promotes growth of prostate cancer cells. PMID: 21871180
- MED19 is a novel proliferation regulator that promotes growth of lung cancer cells PMID: 21519921
- results provide new evidence of an important role for Med19 in the development of hepatocellular carcinomas PMID: 21372827
- upregulated expression of Med19 was found in breast cancer tissues; Med19 expression was significantly associated with tumor grade PMID: 20890603
- LCMR1 was strongly overexpressed in NSCLC and its expression was significantly associated with clinical stage. PMID: 21306606
- MED19 played an important role in cell growth and cell cycle progression of human osteosarcoma cells. PMID: 21542455
- findings identify MED19/MED26 as a probable composite REST interface in Mediator and further clarify the mechanistic basis by which Mediator facilitates REST-imposed epigenetic restrictions on neuronal gene expression PMID: 19049968
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亞細(xì)胞定位：Nucleus.
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蛋白家族：Mediator complex subunit 19 family
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數(shù)據(jù)庫(kù)鏈接：
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