MED17 Antibody, Biotin conjugated
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中文名稱：MED17兔多克隆抗體, Biotin偶聯(lián)
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貨號：CSB-PA865147LD01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) MED17 Polyclonal antibody
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Uniprot No.：
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基因名：MED17
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別名：77-KD subunit antibody; Activator recruited cofactor 77 kDa component antibody; Activator-recruited cofactor 77 kDa component antibody; ARC77 antibody; Cofactor required for Sp1 transcriptional activation subunit 6 antibody; cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa antibody; CRSP complex subunit 6 antibody; CRSP6 antibody; CRSP77 antibody; DRIP80 antibody; med17 antibody; MED17_HUMAN antibody; Mediator complex subunit 17 antibody; Mediator of RNA polymerase II transcription subunit 17 antibody; Mediator of RNA polymerase II transcription subunit 17, S cerevisiae, homolog of antibody; Thyroid hormone receptor-associated protein complex 80 kDa component antibody; Thyroid hormone receptor-associated protein, 80-KD subunit antibody; Transcriptional coactivator CRSP77 antibody; Trap80 antibody; VITAMIN D RECEPTOR-INTERACTING PROTEIN, 80-KD antibody; Vitamin D3 receptor-interacting protein complex 80 kDa component antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Mediator of RNA polymerase II transcription subunit 17 protein (411-651AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關產(chǎn)品
靶點詳情
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功能：Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
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基因功能參考文獻：
- These findings suggest that hMED17 may play essential roles in switching between transcription and nucleotide excision repair. PMID: 25482373
- TRAP80 is a selective regulator of hepatic lipogenesis and is required for LXR-dependent SREBP-1c activation. PMID: 25437875
- Studies indicate that the activation domain of p53 (p53AD) binds directly to the MED17 subunit of Mediator, whereas the p53 C-terminal domain (p53CTD) binds the MED1 subunit. PMID: 21326907
- the p. L371P mutation in MED17 is a founder mutation in the Caucasus Jewish community and that homozygosity for this mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination. PMID: 20950787
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相關疾病：Microcephaly, postnatal progressive, with seizures and brain atrophy (MCPHSBA)
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亞細胞定位：Nucleus.
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蛋白家族：Mediator complex subunit 17 family
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組織特異性：Ubiquitous.
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數(shù)據(jù)庫鏈接：
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