MEAF6 Antibody

中文名稱：

MEAF6兔多克隆抗體
貨號：

CSB-PA872530LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA872530LA01HU diluted at 1:200 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MEAF6 Polyclonal antibody
Uniprot No.：

Q9HAF1
基因名：

MEAF6
別名：

MEAF6 antibody; C1orf149 antibody; CENP-28 antibody; EAF6Chromatin modification-related protein MEAF6 antibody; MYST/Esa1-associated factor 6 antibody; Esa1-associated factor 6 homolog antibody; Protein EAF6 homolog antibody; hEAF6 antibody; Sarcoma antigen NY-SAR-91 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Chromatin modification-related protein MEAF6 protein (113-174AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，MEAF6 Antibody (CSB-PA872530LA01HU)，的標記方式是Non-conjugated。對于MEAF6 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA872530LB01HU	MEAF6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA872530LC01HU	MEAF6 Antibody, FITC conjugated
Biotin	CSB-PA872530LD01HU	MEAF6 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
基因功能參考文獻：
1. These findings suggest that the MEAF6-1 variant does not induce neuroendocrine differentiation of prostate cancer cells, but rather facilitates t-NEPC progression by increasing the proliferation rate of cells that have acquired neuroendocrine phenotypes. PMID: 28427194
2. present two more ESS with MEAF6/PHF1 detected by transcriptome sequencing (case 1) and RT-PCR (case 2), proving that this fusion is recurrent in ESS PMID: 24530230
相關疾病：

A chromosomal aberration involving MEAF6 may be a cause of endometrial stromal tumors. Translocation t(1;6)(p34;p21) with PHF1.
亞細胞定位：

Nucleus, nucleolus. Chromosome, centromere, kinetochore.
蛋白家族：

EAF6 family
數據庫鏈接：

HGNC: 25674

OMIM: 611001

KEGG: hsa:64769

UniGene: Hs.17118

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