MBNL3 Antibody

中文名稱：

MBNL3兔多克隆抗體
貨號：

CSB-PA868322LA01HU
規(guī)格：

￥440
圖片：
IHC image of CSB-PA868322LA01HU diluted at 1:400 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of HepG2 cells with CSB-PA868322LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) MBNL3 Polyclonal antibody
Uniprot No.：

Q9NUK0
基因名：

MBNL3
別名：

A530038J18Rik antibody; AI661274 antibody; CHCR antibody; Cys3His CCG1 required protein antibody; Cys3His CCG1-required protein antibody; E430034C16Rik antibody; MBLX antibody; MBLX39 antibody; MBNL 3 antibody; Mbnl3 antibody; MBNL3_HUMAN antibody; MBXL antibody; Muscleblind like 3 antibody; Muscleblind like protein 3 antibody; Muscleblind like splicing regulator 3 antibody; Muscleblind like X linked protein antibody; Muscleblind-like protein 3 antibody; Muscleblind-like X-linked protein antibody; OTTMUSP00000019072 antibody; OTTMUSP00000019073 antibody; OTTMUSP00000019074 antibody; Protein HCHCR antibody; RP23-98P13.1 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Muscleblind-like protein 3 protein (116-211AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，MBNL3 Antibody (CSB-PA868322LA01HU)，的標(biāo)記方式是Non-conjugated。對于MBNL3 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA868322LB01HU	MBNL3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA868322LC01HU	MBNL3 Antibody, FITC conjugated
Biotin	CSB-PA868322LD01HU	MBNL3 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction.
基因功能參考文獻：
1. The MBNL3 splicing factor promotes hepatocellular carcinoma by increasing pacillin expression through the alternative splicing of lncRNA-PXN-AS1. PMID: 28553938
2. results suggest that CHCR is an inhibitor of myogenesis PMID: 12297108
3. MBNL proteins promote opposite splicing patterns for cardiac troponin T and insulin receptor alternative exons PMID: 15257297
4. We exclude MBNL3 as the causative gene in this family. PMID: 17102799
5. MBNL3 was not found in human samples. PMID: 19095965
顯示更多

收起更多
亞細胞定位：

Nucleus. Cytoplasm. Note=Greater concentration in the nucleus. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts.
蛋白家族：

Muscleblind family
組織特異性：

Highly expressed in the placenta.
數(shù)據(jù)庫鏈接：

HGNC: 20564

OMIM: 300413

KEGG: hsa:55796

STRING: 9606.ENSP00000359890

UniGene: Hs.105134

YWHAG Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
YWHAB Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF, FC

Species Reactivity: Human, Mouse, Rat
XRCC5 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF

Species Reactivity: Human
XPNPEP1 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
XDH Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WT1 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WFDC2 Recombinant Monoclonal Antibody

Applications: ELISA, WB, FC

Species Reactivity: Human
WDR5 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human