MAT2A Antibody, Biotin conjugated

說明書

中文名稱：

MAT2A兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA013517LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MAT2A Polyclonal antibody
Uniprot No.：

P31153
基因名：

MAT2A
別名：

AdoMet synthase 2 antibody; AdoMet synthetase 2 antibody; AdoMet synthetase antibody; AMS 2 antibody; AMS2 antibody; MAT 2 antibody; MAT 2A antibody; MAT II antibody; MAT-II antibody; Mat2a antibody; MATA 2 antibody; MATA2 antibody; MATII antibody; Methionine adenosyltransferase 2 antibody; Methionine adenosyltransferase antibody; Methionine adenosyltransferase II alpha antibody; Methionine adenosyltransferase II antibody; METK2_HUMAN antibody; S adenosylmethionine synthetase gamma form antibody; S adenosylmethionine synthetase isoform type 2 antibody; S-adenosylmethionine synthase isoform type-2 antibody; SAMS 2 antibody; SAMS2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human S-adenosylmethionine synthase isoform type-2 protein (1-395AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
基因功能參考文獻：
1. MAT2A expression is upregulated through mRNA stabilization upon SAM depletion. PMID: 29262316
2. Increased MAT2A expression is associated with recurrence in hepatocellular carcinoma. PMID: 29448301
3. High MAT2A expression is associated with tamoxifen-resistant breast cancer. PMID: 26418898
4. METTL16 that controls MAT2A intron retention in response to intracellular SAM levels; splicing of the MAT2A retained intron is rapidly induced upon Met depletion, and this effect requires a conserved hairpin which is a METTL16 m6A substrate. PMID: 28525753
5. methionine adenosyltransferase II alpha (MAT2A), and the arginine methyltransferase, PRMT5, as vulnerable enzymes in cells with MTAP deletion. PMID: 27068473
6. crystal structures of human MATalpha2 containing various bound ligands. PMID: 26858410
7. acetylation decreased in hepatocellular cancer PMID: 25925782
8. Mutagenesis of MATalpha2 and MATbeta phospho-sites destabilized them and prevented hepatic stellate cell trans-differentiation. PMID: 25294683
9. The data presented here support the conclusion that rare genetic variants in MAT2A predispose individuals to thoracic aortic disease. PMID: 25557781
10. Results suggest that MAT2A is downregulated in cancer tissues of renal cell carcinomas patients and has function of tumor suppressor though repressing the expression of heme oxygenase-1. PMID: 24636201
11. Differential gene expression of BACE1 and PSEN1 in the knockdown cells, which is possibly a consequence of MAT2A deregulation and may indicate a self regulatory mechanism. PMID: 22879628
12. hypoxia-induced MAT2A expression is HIF-1alpha dependent PMID: 21460102
13. Insulin-like growth factor 1 (IGF1) activates methionine adenosyltransferase 2A MAT2A) transcription by both known and novel pathways in colon cancer cells. PMID: 21406062
14. X protein of hepatitis B virus inhibits apoptosis in hepatoma cells through enhancing the methionine adenosyltransferase 2A gene expression and reducing S-adenosylmethionine production PMID: 21247894
15. regulation of expression in hepatocarcinoma cells by L-methionine availability PMID: 12660248
16. beta subunit associates with cirrhosis and cancer providing a proliferative advantage in hepatoma cells through its interaction with methionine adenosyltransferase II alpha2 and down-regulation of S-adenosylmethionine levels. PMID: 12671891
17. up-regulation of MAT2A also provides a growth advantage and s-adenosylmethionine and methylthioadenosine can block mitogenic signaling in colon cancer cells PMID: 17631143
18. Lower expression of both MAT2A and MAT2beta and interfere with leptin signaling in liver cancer cells. PMID: 18041713
19. This work was carried out to examine the role of MAT II activity and S-adenosylmethionine biosynthesis in the survival of leukemic T cells. PMID: 19048023
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蛋白家族：

AdoMet synthase family
組織特異性：

Detected in kidney.
數據庫鏈接：

HGNC: 6904

OMIM: 601468

KEGG: hsa:4144

STRING: 9606.ENSP00000303147

UniGene: Hs.516157

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