MAS1 Antibody

中文名稱：

MAS1兔多克隆抗體
貨號：

CSB-PA013505LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in:U251 whole cell lysate, A375 whole cell lysate
All lanes: MAS1 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 38 kDa
Observed band size: 38 kDa

Immunofluorescence staining of Hela cell with CSB-PA013505LA01HU at 1:180, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Immunofluorescence staining of Hela cell with 5% goat serum, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品描述：

The CSB-PA013505LA01HU product is a polyclonal antibody targeting the MAS1 protein. To generate it, a rabbit was inoculated with the recombinant human proto-oncogene Mas protein (285-325aa). Protein G affinity chromatography was used to purify the antibody, resulting in an ultra-high purity level of up to 95%.

This MAS1 polyclonal antibody is reactive with human and mouse samples, and it can recognize the MAS1 protein. Multiple rigorous validations have been conducted on this antibody, demonstrating its efficacy in various applications such as ELISA, WB, IHC, and IF. Therefore, this antibody can be used to quantify LIPA protein levels, identify its presence and size, and localize the MAS1 protein.
產品名稱：

Rabbit anti-Homo sapiens (Human) MAS1 Polyclonal antibody
Uniprot No.：

P04201
基因名：

MAS1
別名：

MAS1; MAS; Proto-oncogene Mas
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Proto-oncogene Mas protein (285-325AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，MAS1 Antibody (CSB-PA013505LA01HU)，的標記方式是Non-conjugated。對于MAS1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA013505LB01HU	MAS1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA013505LC01HU	MAS1 Antibody, FITC conjugated
Biotin	CSB-PA013505LD01HU	MAS1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IF	1:100-1:300

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Receptor for angiotensin 1-7. Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.
基因功能參考文獻：
1. These findings suggest a critical role for MasR in cardiomyocyte survival. PMID: 29052864
2. ANG-(1-7) acts on the receptor MAS to influence a range of mechanisms in the heart, kidney, brain, and other tissues. [review] PMID: 29351514
3. These findings suggest that mitochondrial assembly receptor signaling may be a promising novel target for oral tongue squamous cell carcinoma. PMID: 28747140
4. High levels of MAS is associated with angiogenesis in bladder cancer. PMID: 28599664
5. Here, we review the role and effects of ACE2, ACE2 activators, Ang-(1-7) and synthetic Mas receptor agonists in the control of inflammation and fibrosis in cardiovascular and renal diseases and as counter-regulators of the ACE-Ang II-AT1 axis. PMID: 26995300
6. Downregulation of ACE2/Ang-(1-7)/Mas axis stimulates breast cancer metastasis through the activation of store-operated calcium entry and PAK1/NF-kappaB/Snail1 pathways. PMID: 27063099
7. These results indicated that angiotensin-(1-7)/ACE2/Mas axis may reduce liver lipid accumulation partly by regulating lipid-metabolizing genes through ATP/P2 receptor/CaM signaling pathway. PMID: 26883384
8. Ang-(1-7) downregulated AT1R mRNA, upregulated mRNA levels of Ang II type 2 receptor (AT2R) and Mas receptor (MasR) and p38-MAPK phosphorylation and suppressed H22 cell-endothelial cell communication PMID: 26225830
9. MAS1 might act as an inhibitory regulator of breast cancer. PMID: 26080617
10. Data show that MAS receptor exhibited constitutive activity that was inhibited by the non-peptide inverse agonist. PMID: 25068582
11. Data suggest that angiotensin converting enzyme 2/angiotensin II-(1-7)/MAS1 axis regulates leukocyte recruitment/activation, cell proliferation, and inflammation/fibrosis; main topic here is kidney/inflammatory renal disease. [REVIEW] PMID: 23488800
12. Up-regulation of the ACE2/Ang-(1-7)/Mas axis protected against pulmonary fibrosis by inhibiting the MAPK/NF-kappaB pathway. PMID: 24168260
13. A proximal promoter construct for the MAS gene was repressed by the SOX [SRY (sex-determining region on the Y chromosome) box] proteins SRY, SOX2, SOX3 and SOX14, of which SRY is known to interact with the KRAB domain. PMID: 24128372
14. Mas appears to be a critical component required for NO-mediated vasodilatation induced by renin angiotensin system-dependent and RAS-independent agonists and therefore arises as a key pharmacological target to modulate endothelial function PMID: 23459756
15. Control of adipogenesis by the autocrine interplays between angiotensin 1-7/Mas receptor and angiotensin II/AT1 receptor signaling pathways. PMID: 23592774
16. MasR was significantly upregulated in colon adenocarcinoma compared with non-neoplastic colon mucosa, which showed little or no expression of it. ACE gene expression and enzymatic activity were also increased in the tumors. PMID: 22048948
17. Activation of Mas during myocardial infarction contributes to ischemia-reperfusion injury and suggest that inhibition of Mas-G(q) signaling may provide a new therapeutic strategy directed at cardioprotection. PMID: 22003054
18. Report expression (pro)renin receptors and angiotensin converting enzyme 2/angiotensin-(1-7)/Mas receptor axis in human aortic valve stenosis. PMID: 21316680
19. Angiotensin-(1-7), its receptor Mas, and ACE2 are expressed in the human ovary PMID: 20674894
20. The immunolocalization of Ang-(1-7) and its receptor Mas in testes of fertile and infertile men suggests that this system may be altered when spermatogenesis is severely impaired. PMID: 20361351
21. the ability of MAS to up-regulate AT(1) receptor levels reflects the constitutive capacity of MAS to activate Galpha(q)/Galpha(11) and hence stimulate PKC-dependent phosphorylation of the AT(1) receptor PMID: 16611642
22. Mas, MrgD, and MRG mediated Ang IV-stimulated AA release that was highest for Mas. While Ang III activated Mas and MrgX2, Ang II stimulated AA release via Mas and MRG. PMID: 18636314
23. The vasoactive peptide angiotensin-(1-7), its receptor Mas and the angiotensin-converting enzyme type 2 are expressed in the human endometrium. PMID: 19164480
24. the Mas oncogene acts as a receptor for Angiotensin (1-7)--REVIEW PMID: 19461648
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相關疾病：

The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells.
亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family
數據庫鏈接：

HGNC: 6899

OMIM: 165180

KEGG: hsa:4142

STRING: 9606.ENSP00000252660

UniGene: Hs.99900

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