MARS Antibody
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中文名稱：MARS兔多克隆抗體
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貨號：CSB-PA013500GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：MARS
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別名：cytoplasmic antibody; FLJ35667 antibody; Mars antibody; Methionine tRNA ligase 1 antibody; Methionine tRNA ligase 1 cytoplasmic antibody; Methionine tRNA ligase antibody; Methionine tRNA synthetase antibody; Methionine--tRNA ligase antibody; Methionyl tRNA synthetase cytoplasmic antibody; Methionyl-tRNA synthetase antibody; MetRS antibody; MRS antibody; MTRNS antibody; SYMC_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human MARS
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus.
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基因功能參考文獻：
- Compound Arg618Cys and Tyr307Cys variants were identified in an infant with syndromic interstitial lung and liver disease. Arg618Cys associated with Charcot-Marie-Tooth disease was inherited from an unaffected father. PMID: 29655802
- MRS is frequently overexpressed in NSCLC. Moreover, MRS is related to mTORC1 activity and its overexpression is associated with poor clinical outcomes, indicating that it has potential as a putative therapeutic target. PMID: 28679377
- Genotype-phenotype correlation analysis suggests most of the interstitial lung and liver disease (ILLD), mutations locate in the catalytic domain of MARS. ILLD and Charcot-Marie-Tooth disease, axonal, type 2U might have different disease mechanism. PMID: 28148924
- analysis of the heterotetrameric complex structure of the glutathione transferase (GST) domains shared among the four MSC components, methionyl-tRNA synthetase (MRS), glutaminyl-prolyl-tRNA synthetase (EPRS), AIMP2 and AIMP3 PMID: 26472928
- identification of a founder mutation in MARS led to the molecular definition of a specific type of pulmonary alveolar proteinosis and will enable carrier screening in the affected community and possibly open new treatment opportunities. PMID: 25913036
- the association of rare MARS variant with late-onset autosomal dominant Charcot-Marie-Tooth neuropathy PMID: 24354524
- The F370L and I523T mutations did not affect the association of MARS with the multisynthetase complex. PMID: 24103465
- Here we present data suggesting that MARS is a very rare novel cause of late-onset CMT2. PMID: 23729695
- Data show that aminoacyl-tRNA synthetase-interacting multifunctional protein-3 (AIMP3)/p18 is released from aminoacyl-tRNA synthetase-interacting multifunctional protein-3 (AIMP3) by UV irradiation-induced stress. PMID: 22106287
- The last 15 residues of the previously defined N-terminal extension of hcMetRS are part of the catalytic domain, whereas the first 252 residues constitute the N-terminal extended domain. PMID: 19064003
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相關疾病：Interstitial lung and liver disease (ILLD); Charcot-Marie-Tooth disease 2U (CMT2U)
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亞細胞定位：Cytoplasm, cytosol. Nucleus, nucleolus.
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蛋白家族：Class-I aminoacyl-tRNA synthetase family
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數據庫鏈接：
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