MARCO Antibody

中文名稱：

MARCO兔多克隆抗體
貨號：

CSB-PA880072ESR2HU
規(guī)格：

￥440
圖片：
Western Blot
Positive WB detected in: JK whole cell lysate(20μg), A549 whole cell lysate(20μg)
All lanes: MARCO antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 53, 64, 75kDa
Observed band size: 53 kDa
Exposure time: 120s
其他：

產(chǎn)品詳情
產(chǎn)品評價
引用文獻(xiàn)
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品描述：

The MARCO antibody was inducibly expressed in a rabbit and the immunogen is the recombinant human MARCO protein (421-520aa). It was purified through antigen affinity chromatography.

The MARCO polyclonal antibody has been validated for its specificity in ELISA, WB, and IHC applications. It can be used for the detection and investigation of human MARCO protein expression in different experiments. MARCO, a scavenger receptor expressed by macrophages and dendritic cells, mainly recognizes and binds to PAMPs thus triggering the immune response resulting in the phagocytosis and destruction of the invading microorganisms by the immune cells.
產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) MARCO Polyclonal antibody
Uniprot No.：

Q9UEW3
基因名：

MARCO
別名：

AI323439 antibody; Ly112 antibody; Macrophage receptor MARCO antibody; Macrophage receptor with collagenous structure antibody; Marco antibody; MARCO_HUMAN antibody; SCARA2 antibody; Scavenger receptor class A member 2 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Macrophage receptor MARCO protein (421-520AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文獻(xiàn)

Single-Cell RNA-Seq Uncovers Cellular Heterogeneity from Deep Fascia in Necrotizing Fasciitis Patients T Wang, L Zhang, W Chen, Y Long,Journal of Inflammation Research,2025

產(chǎn)品評價

靶點詳情

功能：

Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria. Also plays a role in binding of unopsonized particles by alveolar macrophages. Binds to the secretoglobin SCGB3A2.
基因功能參考文獻(xiàn)：
1. the absence of MARCO does not interfere with the efficiency of HSV-1 entry and that the inhibitory effect on viral adsorption by poly(I), a ligand of MARCO, is independent of MARCO. PMID: 29769337
2. High surface expression of SR-A6 facilitates HAdV-C5 infection. PMID: 29522575
3. These data suggest the SRCR domain of MARCO is the key domain in modulating ligand binding, enhancing downstream pro-inflammatory signaling and MARCO-mediated cellular adhesion. PMID: 26888252
4. Expression of MARCO declined progressively as hepatocellular carcinoma condition is aggravated. PMID: 27806438
5. MARCO single nucleotide polymorphisms rs12998782 increases risk to pulmonary tuberculosis in a Chinese Han population. PMID: 28693442
6. CD36 and MARCO are associated with the susceptibility of Chinese Han females to carotid atherosclerosis. Menopausal status may affect the association between gene polymorphisms and carotid atherosclerosis in the female Chinese Han population. PMID: 28866086
7. Increasing MARCO expression by targeting Nrf2 signaling or the Akt-TFEB-MARCO pathway are promising strategies to improve bacterial clearance and survival in postinfluenza bacterial pneumonia. PMID: 28408365
8. results suggest that MARCO polymorphisms may regulate phagocytosis of M. tuberculosis and susceptibility and severity of pulmonary tuberculosis PMID: 27853145
9. this paper shows that key gene of intermediate proinflammatory monocytes, such as MARCO, is expressed three- to fourfold more in juvenile idiopathic arthritis-enthesitis-related arthritis PMID: 27706807
10. this study shows that MARCO modulates inflammatory responses against Cryptococcus neoformans infection PMID: 28298522
11. this translational investigation identified gene candidates, including Marco, for host susceptibility to multiple phenotypes of RSV disease in mice that closely mimic human disease, and a polymorphism in human MARCO associated with increased risk of RSV disease severity in infants. PMID: 27554839
12. Identifying N-linked glycan moiety and motifs in the cysteine-rich domain critical for N-glycosylation and intracellular trafficking of SR-AI and MARCO. PMID: 26892079
13. identified as a disease-associated molecule in IgG4-related disease by DNA microarray PMID: 26886650
14. None of the nonsynonymous variants discovered by resequencing of the structurally similar MARCO were associated with lung function or risk of COPD. PMID: 25186548
15. Vaccinia virus bound directly to MARCO, and overexpression of MARCO increased susceptibility to vaccinia infection. PMID: 25089661
16. Significant associations of four SNPs and haplotypes with antibody response to cholera vaccine in three genes, MARCO, TNFAIP3 and CXCL12. PMID: 23249958
17. herpes simplex virus type 1 binds to MARCO to enhance its capacity for disease. PMID: 23739639
18. We identified 9 non-synonymous variants in the MARCO gene and showed that these variants are not major risk factors for COPD or lung infection. H101Q heterozygotes had increased sepsis risk. PMID: 23154236
19. Polymorphisms within the human class A scavenger receptor MARCO correlate with susceptibility/resistance to tuberculosis in a Gambian population. PMID: 23617307
20. In this review, we showed that SR-A and MARCO trigger intracellular signaling, modulating pro-inflammatory and microbicidal activities of macrophages. PMID: 22470185
21. This review demonstrated that class A SR and MARCO are major pattern recognition receptors mediating opsonin-independent phagocytosis. PMID: 22470186
22. genetic variants in MARCO gene were associated with pulmonary tuberculosis susceptibility in Chinese Han population PMID: 21886847
23. These results demonstrate that the S. mutans lipoprotein PpiA contributes to suppression of MARCO-mediated phagocytosis of this bacterium by macrophages. PMID: 21986627
24. Data suggest that bacteria induce glial cell activation and rCRAMP expression via FPRL1 and MARCO, and these receptors contribute to the host defence against infection. PMID: 21299846
25. MARCO is an important phagocytic receptor used by human and mouse macrophages to clear C. sordellii from the infected uterus PMID: 20810988
26. An arginine-rich segment in domain V of MARCO and particularly its RXR motifs play a critical role in high-affinity bacterial binding. PMID: 11820786
27. characterization of a MARCO protein domain involved in binding to bacteria PMID: 12097327
28. Northern blot and in situ hybridization experiments indicate that MARCO is expressed by alveolar macrophages in the lung; retroviral vector-mediated expression cloning determines that MARCO is a receptor for UGRP1. PMID: 12847263
29. a dominant role for MARCO in the human AM defense against inhaled particles and pathogens. PMID: 16237101
30. Expansion of small sputum macrophages in cystic fibrosis shows a failure to express MARCO and CD206. PMID: 19403625
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亞細(xì)胞定位：

Cell membrane; Single-pass type II membrane protein.
組織特異性：

Expressed in alveolar macrophages (at protein level). Detected in macrophages from various tissues including thymus, kidney, Kupffer cells of liver, and spleen.
數(shù)據(jù)庫鏈接：

HGNC: 6895

OMIM: 604870

KEGG: hsa:8685

STRING: 9606.ENSP00000318916

UniGene: Hs.67726

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