MAPRE2 Antibody, Biotin conjugated
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中文名稱：MAPRE2兔多克隆抗體, Biotin偶聯(lián)
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貨號：CSB-PA618987LD01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) MAPRE2 Polyclonal antibody
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Uniprot No.：
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基因名：MAPRE2
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別名：APC binding protein EB1 antibody; APC binding protein EB2 antibody; APC-binding protein EB2 antibody; EB1 antibody; EB2 antibody; End binding protein 2 antibody; End-binding protein 2 antibody; H.sapiens mRNA for novel T cell activation protein antibody; MAPRE2 antibody; MARE2_HUMAN antibody; Microtubule associated protein RP/EB family member 2 antibody; Microtubule-associated protein RP/EB family member 2 antibody; RP1 antibody; T cell activation protein EB1 family antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Microtubule-associated protein RP/EB family member 2 protein (159-240AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關產(chǎn)品
靶點詳情
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功能：May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.
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基因功能參考文獻：
- Aurora B and CDK1 temporally regulate the binding affinity of EB2 for microtubules, thereby ensuring kinetochore microtubule dynamics, proper mitotic progression and genome stability. PMID: 27030108
- Mutations in either TUBB or MAPRE2 cause circumferential skin creases Kunze type. PMID: 26637975
- EB2 is evidently important for initial microtubule reorganisation during epithelial polarisation, whereas its downregulation facilitates EB1 and ACF7 microtubule lattice association, microtubule-actin filament co-alignment and bundle formation. PMID: 23813963
- results suggest that EB1 and ClipCG12 act cooperatively to regulate microtubule dynamics (EB1) PMID: 22424550
- heterodimer formation between EB1 and EB3, but not between EB2 and the other two EBs, occurs both in vitro and in cells as revealed by live cell imaging PMID: 20008324
- Data suggest that a functional interaction between EB1 and p150(Glued) is required for microtubule minus end anchoring at centrosomes during the assembly and maintenance of a radial microtubule array. PMID: 12388762
- EB1 may modulate kinetochore microtubule polymerization and/or attachment PMID: 12475954
- results support the novel hypothesis that EB1 overexpression may play a role in the development of esophageal squamous cell carcinoma by affecting APC function and activating the beta-catenin/TCF pathway PMID: 16007168
- Impaired EB1 or APC function generates lesions invisible to the spindle checkpoint and thereby promotes low levels of chromosomal loss (CIN) expected to fuel aneuploidy and possibly tumorigenesis. PMID: 16763565
- These data demonstrate that the COP9 signalosome-dependent protection of EB1 is important for microtubule function. PMID: 17350042
- Crystal structures of the tubulin binding domains of XMAP215 (yeast Stu2p and Drosophila Msps), EB1 (yeast Bim1p and human EB1), and CLIP-170 (human), which reveal diverse tubulin binding interfaces, are reported. PMID: 17889670
- p150Glued may activate and thereby facilitate the recruitment of EB1 to the tips of microtubules to regulate their dynamics. PMID: 18081319
- EB1-tubulin interactions are mediated in part by the same tubulin acidic tails utilized by other MAPs PMID: 19778897
- MAPRE2 is highly expressed in pancreatic cancer cells, and seems to be involved in perineural invasion PMID: 19787265
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相關疾病：Skin creases, congenital symmetric circumferential, 2 (CSCSC2)
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亞細胞定位：Cytoplasm, cytoskeleton. Note=Associated with the microtubule network. Accumulates at the plus end of microtubules.
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蛋白家族：MAPRE family
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組織特異性：Expressed in different tumor cell lines. Up-regulated in activated B- and T-lymphocytes.
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