MAP2K5 Antibody

中文名稱：

MAP2K5兔多克隆抗體
貨號：

CSB-PA615667HA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: HepG2 whole cell lysate, HEK293 whole cell lysate, Rat liver tissue, Mouse liver tissue
All lanes: MAP2K5 antibody at 3.5µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 51, 49, 50, 47 kDa
Observed band size: 51 kDa

Immunofluorescence staining of Hela cells with CSB-PA615667HA01HU at 1:233, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MAP2K5 Polyclonal antibody
Uniprot No.：

Q13163
基因名：

MAP2K5
別名：

Dual specificity mitogen activated protein kinase kinase 5 antibody; Dual specificity mitogen-activated protein kinase kinase 5 antibody; EC 2.7.12.2 antibody; HsT17454 antibody; MAP kinase kinase 5 antibody; MAP kinase kinase MEK5b antibody; MAP2K5 antibody; MAPK/ERK kinase 5 antibody; MAPKK 5 antibody; MAPKK5 antibody; MEK 5 antibody; mitogen-activated protein kinase kinase 5 antibody; MKK5 antibody; MP2K5_HUMAN antibody; PRKMK5 antibody; Protein kinase, mitogen-activated, kinase 5 antibody; SAPKK5 antibody; SKK5 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse, Rat
免疫原：

Recombinant Human Dual specificity mitogen-activated protein kinase kinase 5 protein (1-190AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，MAP2K5 Antibody (CSB-PA615667HA01HU)，的標記方式是Non-conjugated。對于MAP2K5 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA615667HB01HU	MAP2K5 Antibody, HRP conjugated	ELISA
FITC	CSB-PA615667HC01HU	MAP2K5 Antibody, FITC conjugated
Biotin	CSB-PA615667HD01HU	MAP2K5 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IF	1:200-1:500

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.
基因功能參考文獻：
1. When yeast genetic interaction partners held in common between human OPTN and ANG were validated in mammalian cells and zebrafish, MAP2K5 kinase emerged as a potential drug target for amyotrophic lateral sclerosis therapy PMID: 28596290
2. results confirmed the association of BTBD9 and MAP2K5/SKOR1 with primary Restless Legs Syndrome in Chinese population PMID: 28329290
3. Results revealed the expression of MEK5 was higher in tumor tissues and provide evidence that MEK5 plays an important role in colorectal cancer progression. PMID: 27160304
4. Insights into a molecular mechanism by which MEK5 transcriptionally upregulated by Stat3 augments breast cancer cell EMT, which subsequently enhances cancer cell invasion and metastasis. This finding may suggest that Stat3 and MEK5/Erk5 pathways could be an effective therapeutic target for inhibition of breast cancer invasion and metastasis. PMID: 27878304
5. Our findings confirm an association between the BTBD9, MEIS1, and MAP2K5/SKOR1 SNPs and periodic limb movements of sleep in an elderly cohort. PMID: 26498236
6. Specifically, CKS1B and MAP2K5 significantly inhibited hepatitis C viral RNA replication. PACSIN1, by contrast, inhibited hepatitis C virus infection by decreasing the level of viral protein p7. PMID: 24205826
7. High MEK5 expression is associated with colorectal cancer. PMID: 25662172
8. SEC16B, MC4R, MAP2K5 and KCTD15 (rs17782313, rs543874, rs2241423 and rs11084753) polymorphisms are associated with the risk for children obesity in China. PMID: 25637721
9. Periodic leg movements during sleep are associated with polymorphisms in BTBD9, TOX3/BC034767, MEIS1, MAP2K5/SKOR1, and PTPRD PMID: 25142570
10. MiR-330-3p and MAP2K5 are potentially important contributors to mood and anxiety-related traits PMID: 24436253
11. Single nucleotide polymorphism in the MAP2K5 gene is associated with BMI and obesity. PMID: 22594783
12. data indicate that the rs3743354 polymorphism in the MEK5 promoter may affect the risk of developing colorectal cancer PMID: 21861603
13. Variants in MEIS1, BTBD9, and MAP2K5/SKOR1 confer a significant risk of restless legs syndrome in a United States population. PMID: 21925394
14. Genistein can affect the ERK5 MAPK signaling transduction pathway and induce the expressions of apoptosis related proteins to inhibit the proliferation of MDA-MB-231 cells. PMID: 16758967
15. overexpression of MEK5 in APO- MCF-7 breast carcinoma cells shows that this MAPK signaling protein represents a potent survival molecule. PMID: 12219026
16. MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion. MEK5 is a key signalling molecule associated with prostate carcinogenesis. PMID: 12618764
17. alternative splicing of MEK5alpha and MEK5beta may play a critical role in BMK1 activation and subsequent cell proliferation PMID: 14583600
18. nuclear localization of MEK5 and ERK5 is different from that of ERK1/2 and MEK1/2 in resting cells, indicating that each MAPK cascade uses distinct mechanisms PMID: 15075238
19. MEK5 may be one of the Stat3-regulated genes and plays its essential roles in oncogenesis PMID: 15378007
20. Data suggest that HGF-induced effects in some mesothelioma cells are mediated via activation of a novel PI3K/ERK5/Fra-1 feedback pathway PMID: 17872495
21. ERK5 nuclear staining has been shown to be an independent marker of prognosis in CaP, and may prove useful as a stratification tool to identify a more aggressive/metastatic phenotype PMID: 18071319
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蛋白家族：

Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase subfamily
組織特異性：

Expressed in many adult tissues. Abundant in heart and skeletal muscle.
數據庫鏈接：

HGNC: 6845

OMIM: 602520

KEGG: hsa:5607

STRING: 9606.ENSP00000178640

UniGene: Hs.114198

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