MAP1S Antibody

說明書

中文名稱：

MAP1S兔多克隆抗體
貨號：

CSB-PA013407GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q66K74
基因名：

MAP1S
別名：

BPY2-interacting protein 1 antibody; BPY2IP1 antibody; C19orf5 antibody; FLJ10669 antibody; MAP-1S antibody; MAP1S antibody; MAP1S light chain antibody; MAP1S_HUMAN antibody; MAP8 antibody; MGC133087 antibody; microtubule-associated protein 1S antibody; Microtubule-associated protein 8 antibody; Variable charge Y chromosome 2-interacting protein 1 antibody; VCY2-interacting protein 1 antibody; VCY2IP-1 antibody; VCY2IP1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Human MAP1S
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC,IF
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles.
基因功能參考文獻：
1. Results suggested that microtubule associated protein 1S (MAP1S) were up-regulated among Crohn's disease (CD) patients and MAP1S-related autophagy inhibits apoptosis of intestinal epithelial cells (IECs) through Wnt/beta-catenin signaling pathway which might play a vital role in the protection of intestinal mucosal barrier and inhibition the progression of CD. PMID: 28188784
2. Autophagy defects in the degradation of lipid droplets triggered by the MAP1S deficiency may enhance the initiation and development of ccRCC and reduce the survival of ccRCC patients. PMID: 26701856
3. HDAC4 destabilizes MAP1S, suppresses autophagy flux and promotes the accumulation of mHTT aggregates. PMID: 26540094
4. Ddata underline the key role of MAP1S as a global regulator of microbutule stability and demonstrate a new primary function of MAP1S to regulate MT dynamics at the onset of cytokinesis. PMID: 25300793
5. results support a role for MAP1 proteins in promoting efficient retrograde trafficking of HIV-1 by stimulating the formation of stable microtubules and mediating the association of HIV-1 cores with microtubules. PMID: 25505242
6. The PU.1-regulated MAP1S gene is implicated in neutrophil differentiation and autophagy control. PMID: 25043887
7. clarify roles of MAP1S in bridging microtubules and mitochondria with autophagic and mitophagic initiation, maturation, trafficking, and lysosomal clearance. PMID: 21262964
8. The amino acid sequence of VCY2IP-1 shows 59.3% and 41.9% homology to two human microtubule-associated proteins (MAPs), MAP1B and MAP1A, respectively. VCY2IP-1 has an extensive homology to the N-terminus and C-terminus regions of MAP1B and MAP1A PMID: 14627543
9. is expressed in a wide range of tissues in addition to neurons and represents the non-neuronal counterpart of a cytolinker family PMID: 15528209
10. Deletion mutagenesis indicated that C19ORF5 selectively binds double stranded DNA through its microtubule binding domain. PMID: 15907802
11. These results suggest that the interaction of SOCS3 with MAP1S and the integrity of the microtubule cytoskeleton play an important role in the negative regulation of SOCS3 on IL-6 signaling. PMID: 19027008
12. C19ORF5 distributed broadly across the mitotic spindle and reversibly accumulated during reversible mitotic arrest. PMID: 19759419
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亞細胞定位：

Nucleus. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle.
蛋白家族：

MAP1 family
組織特異性：

Expressed in neurons (at protein level). Expressed in spermatocytes, spermatids and spermatozoa. Expressed in the cerebral cortex. Highly expressed in testis. Moderately expressed in the brain, colon, heart, kidney, liver, lung, placenta, small intestine,
數據庫鏈接：

HGNC: 15715

OMIM: 607573

KEGG: hsa:55201

STRING: 9606.ENSP00000325313

UniGene: Hs.66048

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