Ly75 Antibody

中文名稱：

Ly75兔多克隆抗體
貨號：

CSB-PA013251HA01MO
規格：

￥440
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Mus musculus (Mouse) Ly75 Polyclonal antibody
Uniprot No.：

Q60767
基因名：

Ly75
別名：

Ly75 antibody; Cd205 antibody; Lymphocyte antigen 75 antibody; Ly-75 antibody; DEC-205 antibody; CD antigen CD205 antibody
宿主：

Rabbit
反應種屬：

Mouse
免疫原：

Recombinant Mouse Lymphocyte antigen 75 protein (28-211AA)
免疫原種屬：

Mus musculus (Mouse)

標記方式：

Non-conjugated

本頁面中的產品，Ly75 Antibody (CSB-PA013251HA01MO)，的標記方式是Non-conjugated。對于Ly75 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA013251HB01MO	Ly75 Antibody, HRP conjugated	ELISA
FITC	CSB-PA013251HC01MO	Ly75 Antibody, FITC conjugated
Biotin	CSB-PA013251HD01MO	Ly75 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment. Causes reduced proliferation of B lymphocytes.
基因功能參考文獻：
1. this study shows that CD205-TLR9-IL-12 axis contributes to CpG-induced oversensitive liver injury in Hepatitis B viral antigens transgenic mice by promoting the interaction of NKT cells with Kupffer cells PMID: 27041637
2. DNA vaccines encoding DEC205-targeted antigens induce peripheral tolerance rather than immunity PMID: 25819746
3. The DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8 T cells independently of PD-1 and PD-L1. PMID: 24021877
4. Through analysis of both polyclonal and monoclonal transgenic TCR T-cell development in the context of CD205 deficiency, we demonstrate that CD205 does not play an overt role in T cell development or selection. PMID: 23300927
5. Introduction of a labile dipeptide linker at the N terminus of a T-cell epitope improves proteasome-dependent class I MHC-restricted peptide cross-presentation when delivered by alphaDEC205 in vitro and in vivo. PMID: 23297227
6. Data indicate that the interaction between the PE-Cy5.5 conjugates and the cells expressing mDEC205 appears distinctive, since none of the PE-Cy5.5 conjugates bind to the cells that express human DEC205 on surface. PMID: 22841832
7. CD205+ conventional dendritic cells impacts the regulation of T-cell immunity and homeostasis in vivo PMID: 22736794
8. Langerin-positive dendritic cells appear to be the predominant, though not exclusive, population responsible for in vivo transport of anti-DEC-205 antibodies from the skin to the draining lymph nodes in steady state and inflammation. PMID: 22291181
9. For production of cytotoxic T cells, DEC-205 and Clec9A, but not Clec12A, are effective targets for antibody-mediated delivery of antigens for vaccination, although only in the presence of adjuvants. PMID: 21677141
10. Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A. PMID: 21262813
11. show that Flt3L DC efficiently crosspresent HIV gag via the DEC-205 receptor, about 100 times more effective than non-targeted gag. PMID: 19830741
12. Results suggest that DEC-205 provides an efficient receptor-based mechanism for dendritic cells to process proteins for MHC class I presentation in vivo, leading to tolerance in the steady state and immunity after dendritic cell maturation. PMID: 12486105
13. This protein was detected in mouse Langerhans cells on epidermis separated by microwave irradiation. PMID: 12503727
14. Dendritic cell targeting via the DEC205 receptor in the presence of anti-CD40 and poly(I:C) as maturation stimuli, induced strong human and mouse survivin-specific CD4+ T cell responses PMID: 17142738
15. murine DEC-205 is a receptor for PLA of Yersinia pestis PMID: 18650418
16. CD205 acts as a recognition receptor for dying cells, potentially providing an important pathway for the uptake of self-antigen in intrathymic and peripheral tolerance. PMID: 19135256
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亞細胞定位：

Membrane; Single-pass type I membrane protein.
組織特異性：

Expressed in dendritic and thymic epithelial cells and lymph nodes.
數據庫鏈接：

KEGG: mmu:17076

STRING: 10090.ENSMUSP00000028362

UniGene: Mm.2074

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