Loxl1 Antibody, FITC conjugated
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中文名稱：Loxl1兔多克隆抗體, FITC偶聯
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貨號：CSB-PA013040LC01MO
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Mus musculus (Mouse) Loxl1 Polyclonal antibody
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Uniprot No.：
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基因名：Loxl1
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別名：Loxl1 antibody; Lox2 antibody; Loxl antibody; Lysyl oxidase homolog 1 antibody; EC 1.4.3.- antibody; Lysyl oxidase 2 antibody; Lysyl oxidase-like protein 1 antibody
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宿主：Rabbit
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反應種屬：Mouse
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免疫原：Recombinant Mouse Lysyl oxidase homolog 1 protein (95-607AA)
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免疫原種屬：Mus musculus (Mouse)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Active on elastin and collagen substrates.
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基因功能參考文獻：
- findings strongly suggested that elastin crosslinking and LOXL1 were co-associated with liver cirrhosis, while selective inhibition of LOXL1 arrested disease progression by reducing crosslinking of elastin. PMID: 29366776
- LOXL1-/- mutant mice develop appendicular and axial skeletal phenotypes characterized by decreased bone volume fraction and compromised trabecular microstructure, predominantly in females PMID: 26538021
- Elimination of LOXL1 in mice impairs the blood-aqueous humor barrier in the ocular anterior segment and causes lens abnormalities consistent with cataract formation, but does not result in deposition of macromolecular material or glaucoma. PMID: 24425853
- There is a possible fundamental role of LOXL-1 in cardiac hypertrophy. PMID: 22763477
- loxl appears non-allelic to rough coat in mice; heart- and skin-specific downregulation of LOXL in rough coat mice, however, may contribute to the extracellular matrix alterations and the rough coat phenotype PMID: 15482472
- Data report that cells in the hippocampal granule cell layer of LOXL -/- mice have significantly smaller somas and muted long-term potentiation compared to LOXL +/+ mice. PMID: 16157454
- LOXL1 deficiency caused failure of elastic fiber homeostasis leading to pelvic floor disorders PMID: 16436666
- LOXL1 (lysyl oxidase-like 1) mutation results in a global defect in connective tissues and correlates with altered biomechanical behavior of the vagina and supportive tissues PMID: 18265927
- LOXL1-KO lower urogenital tract anatomical and functional phenotype resembles female pelvic floor dysfunction in humans. Elastin disorganization may lead to such functional abnormalities. PMID: 18495804
- Loxl1(-/-) males bred with control females demonstrated relative fecundity values intermediate between Loxl1(-/-) pairs (lowest fecundity) and control pairs (highest fecundity), suggesting a component of male-factor infertility. PMID: 19201700
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亞細胞定位：Secreted, extracellular space.
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蛋白家族：Lysyl oxidase family
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數據庫鏈接：
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