Immunohistochemistry analysis of human testis tissue using CSB-PA013249LA01HU at dilution of 1:100
Immunohistochemistry analysis of human tonsil tissue using CSB-PA013249LA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA013249LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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貨期:
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用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons.
亞細胞定位:
Cell membrane; Lipid-anchor, GPI-anchor.
組織特異性:
Highly expressed in brain (cerebral cortex, amygdala, hippocampus and subthalamic nucleus) and in acute human leukemic cell line MOLT-3. Also found in lower levels in testis, pancreas, small intestine and colon.