LSR Antibody

中文名稱：

LSR兔多克隆抗體
貨號：

CSB-PA801252LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA801252LA01HU diluted at 1:400 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of HepG2 cells with CSB-PA801252LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) LSR Polyclonal antibody
Uniprot No.：

Q86X29
基因名：

LSR
別名：

ILDR3 antibody; Immunoglobulin like domain containing receptor 3 antibody; Lipolysis Stimulated Lipoprotein Receptor antibody; Lipolysis stimulated remnant antibody; Lipolysis-stimulated lipoprotein receptor antibody; LISCH antibody; LISCH protein antibody; LISCH7 antibody; Liver specific bHLH Zip transcription factor antibody; LSR antibody; LSR_HUMAN antibody; MGC10659 antibody; MGC48312 antibody; MGC48503 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Lipolysis-stimulated lipoprotein receptor protein (112-233AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，LSR Antibody (CSB-PA801252LA01HU)，的標記方式是Non-conjugated。對于LSR Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA801252LB01HU	LSR Antibody, HRP conjugated	ELISA
FITC	CSB-PA801252LC01HU	LSR Antibody, FITC conjugated
Biotin	CSB-PA801252LD01HU	LSR Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells.
基因功能參考文獻：
1. this study shows that loss of tricellular tight junction protein LSR promotes cell invasion and migration via upregulation of TEAD1/AREG in endometrial cancer PMID: 28071680
2. Lipolysis-stimulated lipoprotein receptor (LSR)-deficient CaCo-2 cells exhibited increased cell proliferation. PMID: 27391068
3. Results of this study provide novel evidence that tricellular tight junctions protein LSR negatively regulates cancer cell progression and development in endometrial cancer. PMID: 27036040
4. Lipolysis-stimulated lipoprotein receptors (LSRs) localized to bicellular junctions in association with myosin regulatory light chain 2 (MRLC2) at low cell densities and to tricellular contacts when myosin phosphatase target subunit 1 (MYPT1) localized to the bicellular regions. PMID: 28493278
5. analysis of how Clostridium difficile binary toxin CDT interacts with its host cell receptor, Lipolysis-stimulated Lipoprotein Receptor PMID: 25882847
6. These data show that Clostridium difficile binary toxin CDT induces clustering of the lipolysis-stimulated lipoprotein receptor into lipid rafts. PMID: 23631918
7. findings show that Clostridium spiroforme toxin (CST)enters target cells via the lipolysis-stimulated lipoprotein receptor; findings indicate that CST shares LSR with C. difficile CDT and C. perfringens iota toxin as a host cell surface receptor PMID: 22252869
8. LSR defines tricellular contacts in epithelial cellular sheets by acting as a landmark to recruit tricellulin for tricellular tight junction formation. PMID: 21245199
9. LISCH7 may have a role in progression of human colon cancer PMID: 17975147
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亞細胞定位：

Cell membrane; Single-pass membrane protein.
蛋白家族：

Immunoglobulin superfamily, LISCH7 family
數據庫鏈接：

HGNC: 29572

OMIM: 616582

KEGG: hsa:51599

STRING: 9606.ENSP00000354575

UniGene: Hs.466507

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