LRRC32 Antibody, HRP conjugated
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中文名稱：LRRC32兔多克隆抗體, HRP偶聯
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貨號：CSB-PA618886LB01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) LRRC32 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：D11S833E antibody; GARP antibody; Garpin antibody; Glycoprotein A repetitions predominant antibody; Leucine rich repeat containing 32 antibody; Leucine-rich repeat-containing protein 32 antibody; LRC32_HUMAN antibody; LRRC32 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Transforming growth factor beta activator LRRC32 protein (301-500AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta. Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3).
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基因功能參考文獻：
- GARP is a surface molecule of regulatory T cells with roles in the regulatory function and TGF-beta releasing [review] PMID: 27095576
- Data show that the Treg activation marker GARP (glycoprotein A repetitions predominant) is expressed on primary melanoma. PMID: 27248166
- High GARP expression is associated with pancreatic cancer and liver metastases from colorectal cancer. PMID: 26885615
- study showed that stimulated, human B lymphocytes produce active TGF-beta1 from surface GARP/latent TGF-beta1 complexes with isotype switching to IgA production. PMID: 28607112
- GARP plays an important role in the pathogenesis of atopic dermatitis. PMID: 27884290
- CD4(+) CD25(+) GARP(+) Treg cells are defective in dilated cardiomyopathy patients and GARP seems to be a better molecular definition of the regulatory phenotype. PMID: 28207945
- these results define the oncogenic effects of the GARP-TGFbeta axis in the tumor microenvironment PMID: 27913437
- LRRC32 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
- GARP deficiency leads to accumulation of sphingolipid synthesis intermediates, changes in sterol distribution, and lysosomal dysfunction. PMID: 26357016
- since GARP functions as a transporter of transforming growth factor beta (TGFbeta), a cytokine with broad pleiotropic traits, GARP transcriptional attenuation by alternative promoters might provide a mechanism regulating peripheral TGFb PMID: 26584734
- GARP is regulated by miRNAs and controls latent TGF-beta1 production by human regulatory T cells. PMID: 24098777
- we investigated in detail miR-142-3 pregulation of GARP expression in regulatory CD25(+) CD4 T cells PMID: 23650616
- Findings support the idea that GARP is a new latent TGFbeta-binding protein that regulates the bioavailability of TGFbeta and provides a cell surface platform for alphaV integrin-dependent TGFbeta activation. PMID: 22278742
- There are 2 independent signals, one in C11orf30 and the other in LRRC32, that are strongly associated with serum IgE levels. C11orf30-LRRC32 region may represent a common locus for atopic diseases via pathways involved in regulation of serum IgE levels PMID: 22070912
- GARP is a key receptor controlling FOXP3 in T(reg) cells following T-cell activation in a positive feedback loop assisted by LGALS3 and LGMN PMID: 19453521
- the processing and expression of LRRC32 PMID: 21615933
- on chromosome 11q13.5 near the leucine-rich repeat containing 32 gene (LRRC32, also known as GARP) associated with asthma risk PMID: 21907864
- GARP is a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression PMID: 18628982
- Platelets and activated Tregs co-express latent TGF-beta and GARP on their membranes. PMID: 19651619
- Expression of GARP on activated regulatory T cells correlates with their suppressive capacity. PMID: 19666573
- Data show that latent TGF-beta, i.e. both LAP and mature TGF-beta, binds to GARP, which is present on the surface of stimulated Treg clones but not on Th clones. PMID: 19750484
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亞細胞定位：Cell membrane; Single-pass type I membrane protein. Cell surface.
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組織特異性：Preferentially expressed in regulatory T-cells (Tregs).
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