LOXL4 Antibody

說明書

中文名稱：

LOXL4兔多克隆抗體
貨號：

CSB-PA216533
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA216533(LOXL4 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
其他：

產品詳情
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靶點詳情

產品詳情

Uniprot No.：

Q96JB6
基因名：

LOXL4
別名：

4833426I20Rik antibody; FLJ21889 antibody; LOX L4 antibody; LOXC antibody; LOXL 4 antibody; LOXL4 antibody; LOXL4_HUMAN antibody; Lysyl oxidase homolog 4 antibody; Lysyl oxidase like 4 antibody; Lysyl oxidase like protein 4 antibody; Lysyl oxidase related C antibody; Lysyl oxidase related protein C antibody; Lysyl oxidase-like protein 4 antibody; Lysyl oxidase-related protein C antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthetic peptide of Human LOXL4
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May modulate the formation of a collagenous extracellular matrix.
基因功能參考文獻：
1. study describes for the first time a direct link between a retinoic-induced gene and protein, LOXL4, and its general clinical pro-healing properties in ECM dynamics PMID: 27597564
2. Although expression of LOXL4 is not statistically associated with neck metastases, we showed that LOXL4 expression significantly increased in laryngeal cancer. PMID: 26138381
3. In hepatocellular carcinoma, low LOXL4 expression was associated with lower overall survival rates and higher cumulative recurrence rates. PMID: 26097573
4. These results provide a set of the essential genes in this newly identified miR-193a-3p/LOXL4/Oxidative Stress axis. PMID: 25311867
5. High Lysyl oxidase-like 4 promotes proliferation and metastasis of gastric cancer via FAK/Src pathway. PMID: 25216702
6. data suggest that abnormal expression of LOXL4 of KCOT may enhance angiogenesis in KCOT, which may help to promote the locally aggressive biological behavior of KCOT. PMID: 24357854
7. TGF-beta1 induced injured MCL to express more LOXs than injured ACL (up to 1.85-fold in LOX, 2.21-fold in LOXL-1, 1.71-fold in LOXL-2, 2.52-fold in LOXL-3 and 3.32-fold in LOXL-4). PMID: 23357697
8. Alternatively spliced lysyl oxidase-like 4 isoforms have a pro-metastatic role in cancer. PMID: 22806361
9. The human lysyl oxidase-like 4 gene does not confer increased genotypic risk for adolescent idiopathic scoliosis. PMID: 21740577
10. SNPs in the lysyl oxidase-like protein 4 and complement component 3 genes are associated with increased risk for endometriosis and endometriosis-associated infertility in a Puerto Rican population. PMID: 21733505
11. Overexpression of the lysyl oxidase-like 4 gene is associated with metastatic head/neck carcinoma. PMID: 21115907
12. The data presented in this work might emphasize the involvement of LOXL4 in molecular processes of the genesis or progression of head and neck carcinomas. PMID: 12894545
13. LOXL4, with the four scavenger receptor cysteine rich domains, may also function as an active amine oxidase PMID: 14551188
14. Up-regulation of lysyl oxidase mRNA and protein expression is associated with oral squamous cell carcinoma PMID: 17671119
15. LOXL4-DC stimulated T cells produce higher IFN-gamma secretion compared to unstimulated T cells and T cells stimulated with untransfected DCs, in the presence of the pan-DR-epitope (PADRE) PMID: 18202753
16. These results suggest that LOXL4 may function as a negative feedback regulator of TGF-beta1 in cell invasion by inhibiting the metabolism of extracellular matrix (ECM) components. PMID: 18586005
17. Functional analysis of the 5' flanking domain of the LOXL4 gene in head and neck squamous cell carcinoma cells. PMID: 18949373
18. In breast carcinoma, LOXL4 was expressed only in the effusion samples. In malignant mesothelioma, LOXL4 and its splice variants were expressed at all sites. PMID: 19015874
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亞細胞定位：

Secreted, extracellular space.
蛋白家族：

Lysyl oxidase family
組織特異性：

Expressed in many tissues, the highest levels among the tissues studied being in the skeletal muscle, testis and pancreas. Expressed in cartilage.
數據庫鏈接：

HGNC: 17171

OMIM: 607318

KEGG: hsa:84171

STRING: 9606.ENSP00000260702

UniGene: Hs.306814

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