LMX1A Antibody, Biotin conjugated

說明書

中文名稱：

LMX1A兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA848414LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) LMX1A Polyclonal antibody
Uniprot No.：

Q8TE12
基因名：

LMX1A
別名：

HGNC:6653 antibody; LIM homeobox protein 1.1 antibody; LIM homeobox transcription factor 1 alpha antibody; LIM homeobox transcription factor 1-alpha antibody; LIM/homeobox protein 1.1 antibody; LIM/homeobox protein LMX1A antibody; LMX 1 antibody; LMX 1.1 antibody; LMX 1A antibody; LMX-1.1 antibody; LMX1 antibody; LMX1.1 antibody; LMX1A antibody; LMX1A_HUMAN antibody; MGC87616 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human LIM homeobox transcription factor 1-alpha protein (9-86AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae.
基因功能參考文獻：
1. Study revealed an anti-metastatic role of LMX1A in gastric cancer which is mediated by the negative regulation of beta-catenin signaling target genes. PMID: 27061089
2. Polymorphisms of dopamine pathway gene aLMX1A is associated with cognitive performance in Bipolar disorder. PMID: 26534905
3. Lmx1a and Lmx1b expression persists in mature dopaminergic neurons of the substantia nigra pars compacta and the ventral tegmental area. [Review] PMID: 26526610
4. SNPs of the LMX1A gene might be associated with the susceptibility to congenital scoliosis and different clinical phenotypes in the Chinese Han population. PMID: 25099324
5. To our best knowledge, this is the first report demonstrating the application of TAT-LMX1A recombinant protein to enhance hESC differentiation to DA as shown by the expression of DA specific makers. PMID: 25380985
6. LMX1A is weakly methylated in cervical adenocarcinomas compared with controls, in a metastatic stage of cervical cancer. PMID: 24407576
7. higher expression is associated with more advanced neoplasm staging in Chinese patients with pancreatic ductal adenocarcinomas PMID: 23165334
8. these data imply that Sp1 and EZH2 may activate LMX1A expression upon oncogenic stress during cervical cancer development. PMID: 24018208
9. Higher immunostaining intensity for OPN and LMX1A correlated with WHO grades for meningiomas and some gliomas. Contrary to our expectations, LMX1A staining in WHO grade IV gliomas was shown to be weaker than in WHO grade III tumours. PMID: 22882568
10. The Lmx1a can induce desired neuronal lineages from most expressing neural progenitor cells by a mechanism resembling developmental binary cell-fate switching. PMID: 21624811
11. One single nucleotide polymorphisms of lmx1a was strongly associated with the magnitude of training-related gains in verbal working memory PMID: 21435346
12. LMX1A may be a potential biomarker for gastric cancer. PMID: 21159062
13. Genetic variation in LMX1A may increase the risk of developing schizophrenia. PMID: 20570600
14. Did not find evidence for association of any LMX1A SNPs with type 2 diabetes mellitus (T2DM) and conclude that LMX1A does not contribute significantly to T2DM etiology in Pima Indians. PMID: 12062816
15. Lmx1a expression is necessary for the expression of bone morphogenetic protein (BMP), and for the normal generation and differentiation of the dorsal-most spinal cord neurons, the dl1 interneurons. PMID: 15183721
16. Lmx1a may be critical to the development of midbrain dopamine neurons from human embryonic stem cells. PMID: 18832589
17. Data show that three single nucleotide polymor in LMX1A and one in LMX1B are associated with Parkinson's disease. PMID: 19189040
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亞細胞定位：

Nucleus.
組織特異性：

Isoform 1 is expressed in many tissues. Not found in heart, liver, spleen and testis. Relatively highly expressed in fetal brain. Isoform LMX1A-4AB is expressed in testis.
數據庫鏈接：

HGNC: 6653

OMIM: 600298

KEGG: hsa:4009

STRING: 9606.ENSP00000294816

UniGene: Hs.667312

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