LMCD1 Antibody, Biotin conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) LMCD1 Polyclonal antibody
Uniprot No.：

Q9NZU5
基因名：

LMCD1
別名：

Dyxin antibody; LIM and cysteine rich domains 1 antibody; LIM and cysteine rich domains protein 1 antibody; LIM and cysteine-rich domains protein 1 antibody; LMCD1 antibody; LMCD1_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human LIM and cysteine-rich domains protein 1 protein (105-268AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter. Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.
基因功能參考文獻：
1. The rs1800775 [1.31 (1.22-1.42); p = 3.41E-12] in the CETP gene and rs359027 [1.26 (1.16-1.36); p = 2.55E-08] in the LMCD1 gene were significantly associated with LHDLC levels PMID: 26879886
2. Together, our results suggest that LMCD1 mutations are potential oncogenic events in HCC metastasis to promote cell migration through the Rac1-signaling pathway. PMID: 21996735
亞細胞定位：

Cytoplasm. Nucleus.
組織特異性：

Expressed in the heart (at protein level). Expressed in many tissues with highest abundance in skeletal muscle.
數據庫鏈接：

HGNC: 6633

OMIM: 604859

KEGG: hsa:29995

STRING: 9606.ENSP00000157600

UniGene: Hs.475353

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