LIN9 Antibody

中文名稱：

LIN9兔多克隆抗體
貨號：

CSB-PA716370LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA716370LA01HU diluted at 1:800 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) LIN9 Polyclonal antibody
Uniprot No.：

Q5TKA1
基因名：

LIN9
別名：

BARA antibody; Beta subunit-associated regulator of apoptosis antibody; Beta-subunit associated regulator of apoptosis antibody; hLin-9 antibody; huLin-9 antibody; lin-9 antibody; lin9 antibody; LIN9_HUMAN antibody; pRB-associated protein antibody; Protein lin-9 homolog antibody; TGS antibody; TUDOR gene similar protein antibody; Type I interferon receptor beta chain-associated protein antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Protein lin-9 homolog protein (5-103AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，LIN9 Antibody (CSB-PA716370LA01HU)，的標記方式是Non-conjugated。對于LIN9 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA716370LB01HU	LIN9 Antibody, HRP conjugated	ELISA
FITC	CSB-PA716370LC01HU	LIN9 Antibody, FITC conjugated
Biotin	CSB-PA716370LD01HU	LIN9 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:500-1:1000

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition.
基因功能參考文獻：
1. High LIN9 expression is associated with Triple-negative breast cancers. PMID: 28807940
2. The MuvB multiprotein complex, together with B-MYB and FOXM1 (MMB-FOXM1) regulate the expression of mitotic kinesins in breast cancer cells. PMID: 28061449
3. LIN-9 phosphorylation on threonine-96 is required for transcriptional activation of LIN-9 target genes and promotes cell cycle progression. PMID: 24475316
4. Results show that E7 interacts with the B-Myb, FoxM1 and LIN9 components of this activator complex, leading to cooperative transcriptional activation of mitotic genes in primary cells and E7 recruitment to the corresponding promoters. PMID: 24141769
5. Study links hTRM9L and tRNA modifications to inhibition of tumour growth via LIN9 and HIF1-alpha-dependent mechanisms. PMID: 23381944
6. inactivation of LIN9, a subunit of DREAM, results in premature senescence, which can be overcome by the SV40 large T (LT) antigen PMID: 21860417
7. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20360844
8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
9. Human Lin-9 has tumor-suppressing activities and the ability of hLin-9 to inhibit transformation is mediated through its association with pRB. PMID: 15538385
10. Mutation of BARA/LIN-9 restores the expression of E2F target genes. PMID: 16730350
11. Mip/LIN-9 is required for the expression of B-Myb, and both proteins collaborate in the control of the cell cycle progression via the regulation of S phase and cyclin A, cyclin B, and CDK1 PMID: 17098733
12. human LIN-9, together with B-MYB, has a critical role in the activation of genes that are essential for progression into mitosis PMID: 17159899
13. The repressor complex that Mip/LIN-9 forms with p107 takes functional precedence over the transcriptional activation linked to the Mip/LIN-9 and B-Myb interaction. PMID: 17563750
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亞細胞定位：

Nucleus, nucleoplasm. Note=Found in perinucleolar structures. Associated with chromatin.
蛋白家族：

Lin-9 family
組織特異性：

Expressed in thymus and testis.
數據庫鏈接：

HGNC: 30830

OMIM: 609375

KEGG: hsa:286826

STRING: 9606.ENSP00000329102

UniGene: Hs.120817

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