LIM2 Antibody

說明書

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) LIM2 Polyclonal antibody
Uniprot No.：

P55344
基因名：

LIM2
別名：

LIM2; Lens fiber membrane intrinsic protein; MP18; MP19; MP20
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Lens fiber membrane intrinsic protein (25-110AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis.
基因功能參考文獻(xiàn)：
1. A novel missense mutation in LIM2 is responsible for autosomal recessive congenital cataracts. PMID: 27814360
2. we report the absence of mutations in all studied genes in four families with phenotypes associating cataract, mental retardation and microcephaly. PMID: 22103961
3. The genetic mutation in GJA3, GJA8, and LIM2 may slightly contribute to the development of age-related cataracts. PMID: 21386927
4. Since the LIM2 gene promoter does not contain a classic TATA box, the Hsu element may serve as the site for binding the RNA polymerase complex. PMID: 15968979
5. A missense mutation in the LIM2 gene is associated with autosomal recessive presenile cataract in an inbred Iraqi Jewish family PMID: 11917274
6. This study shows the involvement of LIM2 in human congenital cataract. PMID: 18596884
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相關(guān)疾病：

Cataract, multiple types 19 (CTRCT19)
亞細(xì)胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

PMP-22/EMP/MP20 family
組織特異性：

Eye lens specific.
數(shù)據(jù)庫鏈接：

HGNC: 6610

OMIM: 154045

KEGG: hsa:3982

UniGene: Hs.162754

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