LILRA3 Antibody, Biotin conjugated

說明書

中文名稱：

LILRA3兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA836677LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) LILRA3 Polyclonal antibody
Uniprot No.：

Q8N6C8
基因名：

LILRA3
別名：

CD 85E antibody; CD85 antigen-like family member E antibody; CD85e antibody; CD85e antigen antibody; e3 antibody; HM 31 antibody; HM 43 antibody; HM31 antibody; HM43 antibody; ILT 6 antibody; ILT-6 antibody; ILT6 antibody; Immunoglobulin like transcript 6 antibody; Immunoglobulin-like transcript 6 antibody; Leucocyte immunoglobulin like receptor antibody; Leukocyte immunoglobulin like receptor 4 antibody; Leukocyte immunoglobulin like receptor A3 antibody; Leukocyte immunoglobulin like receptor subfamily A (without TM domain) member 3 antibody; Leukocyte immunoglobulin like receptor subfamily A member 3 antibody; Leukocyte immunoglobulin-like receptor 4 antibody; Leukocyte immunoglobulin-like receptor subfamily A member 3 antibody; LILRA 3 antibody; LILRA3 antibody; LIR 4 antibody; LIR-4 antibody; LIR4 antibody; LIRA3_HUMAN antibody; Monocyte inhibitory receptor HM43/HM31 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Leukocyte immunoglobulin-like receptor subfamily A member 3 protein (222-313AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.
基因功能參考文獻：
1. Mutations in the genes glucokinase regulatory protein (GCKR), RNase L (RNASEL), leukocyte immunoglobulin-like receptor 3 (LILRA3), and dynein axonemal heavy chain 10 (DNAH10) segregated with elevated HDLc levels in families, while no mutations associated with low HDLc. PMID: 24891332
2. The homozygous LILRA3 deletion is associated with a higher susceptibility for HIV disease and with a faster disease progression. PMID: 27755104
3. Letter: LILRA3 gene deletion is not involved in the giant cell arteritis and systemic sclerosis predisposition in Spanish patients. PMID: 27462831
4. LILRA3 significantly reversed Nogo-66-mediated inhibition of neurite outgrowth and promoted synapse formation in primary cortical neurons through regulation of the ERK/MEK pathway. PMID: 26826187
5. Experiments point towards a beneficial role for LILRA3 in virus infections, especially in ssRNA viruses, like HIV, that engage TLR8; however, the potentially beneficial role of LILRA3 is abrogated during a HIV infection. PMID: 26969150
6. LILRA3 gene deletion was not associated with Multiple Sclerosis susceptibility and did not affect the age of disease onset, clinical subtype or disease severity. PMID: 26871720
7. Evidence showed lack of significant association between LILRA3 deletion and multiple sclerosis pathogenesis. [meta-analysis] PMID: 26274821
8. LILRA3 is a new susceptibility factor for systemic lupus erythematosus (SLE) and primary Sjogren's syndrome (pSS). It predisposes to certain phenotypes such as leucopenia, thrombocytopenia, autoantibody positivity and increased disease activity. PMID: 24906639
9. The current study was conducted to investigate the association of rs103294 of LILRA3 with benign prostatic hyperplasia risk. PMID: 23615473
10. ILT6 deletion polymorphism does not appear to be a lupus susceptibility gene in South Indian Tamils, but may behave as a genetic modifier of autoantibody phenotype by influencing the production of anti-Ro60 and anti-Ro52 autoantibodies PMID: 24899637
11. LILRA3 is an immunostimulatory molecule, whose deficiency is associated with higher frequency of B-non-Hodgkin's lymphoma. PMID: 24363809
12. functional LILRA3 is a novel genetic risk factor for rheumatoid arthritis (RA), especially in males. It appears to highly predispose to ACPA-positive RA and confers an increased risk of disease severity in patients with early RA. PMID: 24757135
13. Data did not indicate any association of LILRA3 deletion with multiple sclerosis (MS) susceptibility, however, patients negative for the deletion may begin to suffer from MS significantly earlier than patients who are positive. PMID: 23238213
14. LILRA1 and LILRA3 generally display a greater binding preference for binding to HLA-C free heavy chain, particularly following removal of beta2-microglobulin by acid treatment. PMID: 21270408
15. These results suggest that LILRA3 may play a role in chronic inflammatory conditions such as rheumatoid arthritis. PMID: 20595277
16. A deletion of LILRA3 gene was found in a minority of British population PMID: 12651072
17. Six alleles characterised, of which four will encode unique peptides, one of which is likely to directly influence ligand binding. PMID: 12750859
18. Multiple sclerosis associates with LILRA3 deletion. PMID: 19421224
19. ILT6 deficiency may be a genetic risk factor for Sjogren's syndrome. PMID: 19790059
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亞細胞定位：

Secreted.
組織特異性：

Detected in B-cells, and at lower levels in natural killer (NK) cells. Detected in peripheral blood monocytes and lung.
數據庫鏈接：

HGNC: 6604

OMIM: 604818

KEGG: hsa:11026

STRING: 9606.ENSP00000251390

UniGene: Hs.113277

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