LHFPL5 Antibody, FITC conjugated

說明書

中文名稱：

LHFPL5兔多克隆抗體, FITC偶聯
貨號：

CSB-PA844703LC01HU
規格：

￥880
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) LHFPL5 Polyclonal antibody
Uniprot No.：

Q8TAF8
基因名：

LHFPL5
別名：

LHFPL5; TMHS; LHFPL tetraspan subfamily member 5 protein; Lipoma HMGIC fusion partner-like 5 protein; Tetraspan membrane protein of hair cell stereocilia
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human LHFPL tetraspan subfamily member 5 protein (46-99AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Regulates transducer channel conductance and is required for fast channel adaptation.
基因功能參考文獻：
1. two novel variants in LHFPL5, including a unique 3'-UTR splice site variant that is predicted to impact pre-mRNA splicing and regulation through an extended 3'-UTR. PMID: 30177809
2. These findings provide a novel function of LHFPL2 and a novel genetic basis for distal reproductive tract development; they also emphasize the importance of an additional merging phase for proper reproductive tract development. PMID: 26964900
3. LHFPL5 mutation is associated with dysequilibrium syndrome type 2 and sensorineural hearing loss. PMID: 26437881
4. Five microsatellites in the 6p21.31e22.3 region and screening of the LHFPL5 gene by DNA heteroduplex analysis revealed a novel mutation (c.89dup) in one out of 129 unrelated Tunisian families with autosomal recessive nonsyndromic hearing loss. PMID: 21816241
5. These findings establish the importance of TMHS for normal sound transduction in humans. PMID: 16459341
6. Flies with mutations affecting the diaphanous,forked, and CG12026/TMHS genes displayed significant reductions in the amplitude of sound-evoked potentials compared to wild-type flies PMID: 19102128
7. The authors present an overview of the LHFP gene family in mouse and humans PMID: 15905332
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相關疾病：

Deafness, autosomal recessive, 67 (DFNB67)
亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

LHFP family
數據庫鏈接：

HGNC: 21253

OMIM: 609427

KEGG: hsa:222662

STRING: 9606.ENSP00000353346

UniGene: Hs.367947

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