LGI4 Antibody

中文名稱：

LGI4兔多克隆抗體
貨號：

CSB-PA818678LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA818678LA01HU diluted at 1:200 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA818678LA01HU diluted at 1:200 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) LGI4 Polyclonal antibody
Uniprot No.：

Q8N135
基因名：

LGI4
別名：

Leucine rich glioma inactivated gene 4 antibody; Leucine rich glioma inactivated protein 4 antibody; Leucine rich repeat LGI family member 4 antibody; Leucine-rich glioma-inactivated protein 4 antibody; Leucine-rich repeat LGI family member 4 antibody; LGI1 like protein 3 antibody; LGI1-like protein 3 antibody; LGI4 antibody; Lgi4 protein antibody; LGI4_HUMAN antibody; Lgil3 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Leucine-rich repeat LGI family member 4 protein (292-412AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，LGI4 Antibody (CSB-PA818678LA01HU)，的標記方式是Non-conjugated。對于LGI4 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA818678LB01HU	LGI4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA818678LC01HU	LGI4 Antibody, FITC conjugated
Biotin	CSB-PA818678LD01HU	LGI4 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Component of Schwann cell signaling pathway(s) that controls axon segregation and myelin formation.
基因功能參考文獻：
1. in four unrelated multiplex families presenting with severe arthrogryposis multiplex congenital, identified biallelic loss-of-function mutations in LGI4; functional tests showed these germline mutations caused aberrant splicing of the endogenous LGI4 transcript and in a cell-based assay impaired the secretion of truncated LGI4 protein PMID: 28318499
2. Intratumoral heterogeneity of ADAM23 promotes tumor growth and metastasis through LGI4 and nitric oxide signals. PMID: 24662834
3. The positive genotypic association between benign familial infantile convulsions (BFIC)and c.1722G/A polymorphism suggests that LGI4 might contribute to the susceptibility to BFIC. PMID: 19815358
4. Schwann cells are the principal cellular source of Lgi4 in the developing nerve; transgenic Lgi4 binds directly to Adam22 without a requirement for additional membrane associated factors. PMID: 20220021
5. Screening of the LGI4 coding region in BFIC and childhood absence epilepsy (CAE) revealed several frequent exonic polymorphisms. PMID: 14505228
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相關疾病：

Arthrogryposis multiplex congenita, neurogenic, with myelin defect (AMCNMY)
亞細胞定位：

Secreted.
組織特異性：

Widely expressed, with highest expression in brain.
數據庫鏈接：

HGNC: 18712

OMIM: 608303

KEGG: hsa:163175

STRING: 9606.ENSP00000312273

UniGene: Hs.65256

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