LETMD1 Antibody

說明書

中文名稱：

LETMD1兔多克隆抗體
貨號：

CSB-PA053347
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA053347(LETMD1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA053347(LETMD1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q6P1Q0
基因名：

LETMD1
別名：

LETMD1LETM1 domain-containing protein 1 antibody; Cervical cancer 1 proto-oncogene protein p40 antibody; Cervical cancer proto-oncogene 2 protein antibody; HCCR-1 antibody; HCRR-2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Fusion protein of Human LETMD1
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in tumorigenesis and may function as a negative regulator of the p53/TP53.
基因功能參考文獻：
1. Data show that the activation of STAT3 protein upregulated human cervical cancer oncogene (HCCR) expression in gastric cancer cells. PMID: 27052330
2. Demonstrate that HBx-HCCR-E-cadherin regulation pathway might play an important role in HBV-induced hepatocarcinogenesis. PMID: 26470691
3. These findings suggest that HCCR gene is over-expressed in acute leukemia patients and may be a useful biomarker for monitoring minimal residual disease. PMID: 25034723
4. HCCR2 gene plays an important role in the tumorigenesis of leukemia. PMID: 24126909
5. HCCRBP-3 induces tumorigenesis through direct interaction with HCCR-1 in human cancers. PMID: 22851403
6. The data demonstrate that HCCR-1 may be used as a novel predictor for the prognosis of the patients with esophageal squamous cell carcinoma. PMID: 22511601
7. HCCR-1 might play a role in the breast tumourigenesis while the overexpression of HCCR-1 induces the obesity probably by inhibiting the cholesterol-lowering effect of ApoE PMID: 20196787
8. The overexpression of HCCR-2 could enhance the division and proliferation of SMMC 7721 cells. PMID: 21138632
9. induces neoplastic cell transformation and epithelial-mesenchymal transdifferentiation PMID: 20591135
10. Treatment of PANC-1 cells with epidermal growth factor increased HCCR-1 protein level via PI3K/Akt/mTOR signaling. PMID: 20423485
11. Human, similar to bacterial ribosomal protein L14 and yeast L22, gene L14.22 (clone 507E08), over-expressed in gliomas. PMID: 12061725
12. HCCR-2 probably represents a new oncogene that is related to tumorigenesis, functioning as a negative regulator of the p53 tumor suppressor PMID: 12879013
13. HCCR-2 represents an oncoprotein that is related to breast cancer development and regulation of the p53 tumor suppressor. PMID: 14691448
14. HCCR oncoprotein has a role in development of human breast cancer PMID: 16278390
15. These results suggest that the HCCR-1 oncogene expression was regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway. PMID: 16949218
16. These experiments show the biological features of HCCR-1 in the cell, and suggest that uncontrolled expression of HCCR-1 may cause mitochondrial dysfunction. PMID: 18045496
17. Data indicate that the level of HCCR-1 in breast cancer tissues is correlated with the HER2 overexpression, p53 mutation, and ER/PR status, and determination of HCCR-1 levels as options for HER2 testing is promising although it needs further evaluation. PMID: 19208263
18. TCF and beta-catenin binding plays important roles in HCCR-1 oncogene expression. PMID: 19435525
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亞細胞定位：

Mitochondrion outer membrane; Single-pass membrane protein.
組織特異性：

Kidney, liver, skeletal muscle, heart and brain. Overexpressed in various tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon and uterine cervix.
數據庫鏈接：

HGNC: 24241

KEGG: hsa:25875

STRING: 9606.ENSP00000262055

UniGene: Hs.655272

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