LAMB3 Antibody

說明書

中文名稱：

LAMB3兔多克隆抗體
貨號：

CSB-PA678801
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human sarcoma tissue using CSB-PA678801(LAMB3 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)

Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: PC3 cells, Primary antibody: CSB-PA678801(LAMB3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q13751
基因名：

LAMB3
別名：

BM600 125KDA antibody; Epiligrin subunit bata antibody; FLJ99565 antibody; Kalinin B1 chain antibody; Kalinin subunit beta antibody; LAM5 antibody; LAMB3 antibody; LAMB3_HUMAN antibody; Laminin B1k chain antibody; Laminin subunit beta-3 antibody; Laminin-5 subunit beta antibody; LAMNB1 antibody; Nicein subunit beta antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Fusion protein of Human LAMB3
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
基因功能參考文獻：
1. From these results, it was shown that laminin-332 is an essential niche component for the proper differentiation of Interfollicular epidermal stem cells. PMID: 29555367
2. the gentamicin-induced laminin beta3 led to the restoration of laminin 332 assembly, secretion, and deposition within the dermal/epidermal junction, as well as proper polarization of alpha6beta4 integrin in basal keratinocytes PMID: 29946029
3. Results show three specific LAMB3 mutations: c.823-1G>A, c.957ins77 and c.3228+1G>A are carried by 91% of all LAMB3 alleles and that at least one of these three mutations will be carried in junctional epidermolysis bullosa individuals in this Chilean population. PMID: 27480391
4. expression in preoperative biopsy material predictive of perineural invasion in patients with oral squamous cell carcinoma PMID: 27863864
5. The authors have identified a mutation in LAM3 causing lethal epidermolysis bullosa in a Balkan, Hungarian, population. Investigations into the genetic background of its unique carrier group, suggests that the estimated age of the mutation corresponds to the period of Roma migration in the Balkans. PMID: 27062385
6. the tyrosine kinase FAK and the laminin subunit LAMB3 as functional targets of miR-1298. Silencing of FAK or LAMB3 recapitulated the synthetic lethal effects of miR-1298 expression in KRAS-driven cancer cells. PMID: 27698189
7. The expression of fascin-1 and lanminin-5 and the serum levels of fascin-1 and laminin-5 were related to the relapse of patients with non-small cell lung cancer. PMID: 28653739
8. Whole-Exome Sequencing Suggests LAMB3 as a Susceptibility Gene for Morbid Obesity PMID: 27431458
9. Case Reports: Junctional epidermolysis bullosa with LAMB3 splice-site mutations. PMID: 25708563
10. LNbeta3 expression may play a key role in the progression and prognosis of pancreatic ductal adenocarcinoma. PMID: 25032755
11. Screening of ENAM and LAMB3 genes was performed by direct sequencing of genomic DNA from blood samples. PMID: 25769099
12. Case Report: linear IgA/IgG bullous dermatosis with anti-laminin-332 autoantibodies. PMID: 24978847
13. An algorithm combining CLDN10, HMGA2, and LAMB3 transcripts was able to discriminate tumors from BTL samples (94% sensitivity and 96% specificity in validation set). PMID: 25867809
14. Novel LAMB3 mutations cause non-syndromic amelogenesis imperfecta with variable expressivity. PMID: 24494736
15. we report a case of Herlitz junctional epidermolysis bullosa with a novel heterozygous mutation in LAMB3,c.1597G>A (p.Ala533Thr). PMID: 23278291
16. However, to our knowledge, this is the first report of dominant AI due to a LAMB3 mutation in the absence of JEB. PMID: 23632796
17. data further enhance the mutation spectrum of the LAMB3 and the COL7A1 genes, and also underscore the crucial roles of these genes in pathogenesis of epidermolysis bullosa PMID: 23769655
18. an 8-bp deletion (c.3446_3453del GACTGGAG) shifting the reading frame (p.Gly 1149Glufs*8) and a single nucleotide substitution (c.C3431A) generating an in-frame translation termination codon (p.Ser1144*)associated with amelogenesis imperfecta PMID: 23958762
19. Results identify the point during neoplastic progression in epithelia when the tumor suppressor p16 and laminin 5 are expressed and suggest that normal epithelia may use the same mechanism to generate non-dividing, motile cells for wound repair. PMID: 12875969
20. Laminin-5 is a useful biomarker in the evaluation of invasiveness in cervical adenocarcinoma. PMID: 22898004
21. These results suggest that epigenetic activation of LAMB3 and LAMC2 may play an important role in gastric carcinogenesis. PMID: 21345334
22. The LAMB3 rs2566 variant CT/TT genotypes were associated with a significantly increased risk of cervical cancer, compared with the wild type CC genotype. PMID: 20163849
23. Gene LAMB3 detected compound heterozygosity for the nonsense mutation R635X and a novel 2 bp deletion (1587delAG) resulting in a downstream premature termination codon. PMID: 11689492
24. Deletion analysis of laminin-beta3 indicated that the region comprising aa 726 to 875 of laminin-beta3 interacts with rotavirus enterotoxin NSP4. PMID: 15331737
25. In squamous cell carcinoma of the tongue and colorectal carcinoma, laminin 5 beta3 chain is important in the invasiveness of cancer cells. PMID: 15363037
26. homozygous frameshift mutation in LAMB3 was associated to illegitimate splicing leading to non-H junctional epidermolysis bullosa PMID: 15373767
27. DNA analysis revealed a compound heterozygote for mutations 2379delG and Q995X in the LAMB3 gene in Herlitz junctional epidermolysis bullosa PMID: 16147969
28. Multiple second-site mutations, all correcting the germline mutation LAMB3 (628G-->A;Glu210Lys), are present in 2 unrelated non-Herlitz junctional epidermolysis bullosa patients with revertant mosaicism. PMID: 17476356
29. degradation [by Candida species] can exert functional disturbances on basement membrane integrity, possibly aiding Candida cell invasion into tissues PMID: 18284540
30. The expression of LAMB3 mrna was higher in malignant tissue and correlated with the depth of invasion and venous invasion in ESCC. PMID: 18331784
31. c.1945dupG mutation in Herlitz junctional epidermolysis bullosa PMID: 18387282
32. Ln-332 gamma2 may be a therapeutic target against metastatic colon cancer because a lowered beta3:gamma2 ratio would reduce expression of heterotrimeric Ln-332 and increase monomeric gamma2 secretion. PMID: 19383890
33. Histopathology of anti-laminin 5 mucous membrane pemphigoid is characterized by subepidermal blistering and a sparse to moderate superficial lymphohistiocytic infiltrate with neutrophils and/or eosinophils PMID: 19700013
34. Results suggest that laminin (LN)gamma2 and LNbeta3, in conjunction with MMP7, play a key role in the progression of biliary tract cancer. PMID: 19701966
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相關疾病：

Epidermolysis bullosa, junctional, Herlitz type (H-JEB); Generalized atrophic benign epidermolysis bullosa (GABEB); Amelogenesis imperfecta 1A (AI1A)
亞細胞定位：

Secreted, extracellular space, extracellular matrix, basement membrane.
組織特異性：

Found in the basement membranes (major component).
數據庫鏈接：

HGNC: 6490

OMIM: 104530

KEGG: hsa:3914

STRING: 9606.ENSP00000348384

UniGene: Hs.497636

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