LAMB1 Antibody
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中文名稱：LAMB1兔多克隆抗體
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貨號：CSB-PA264957
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規格：￥2024
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圖片：
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Western blot analysis of extracts from HepG2 cells, using LAMB1 antibody. -
Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue using LAMB1 antibody. -
Immunofluorescence analysis of HeLa cells, using LAMB1 antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) LAMB1 Polyclonal antibody
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Uniprot No.：
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基因名：
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthesized peptide derived from C-terminal of Human LAMB1.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC,IF
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 IHC 1:50-1:100 IF 1:100-1:500 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface.
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基因功能參考文獻：
- High cytoplasmic laminin expression is associated with Oral Squamous Cell Carcinomas. PMID: 29479990
- Treatment of Neuroscreen-1 (NS-1) cells with laminin-1 or YIGSR peptide, which corresponds to a sequence in laminin-1 beta1 chain that binds to 67LR, induced a decrease in the cell-surface expression of 67LR and caused its internalization. PMID: 29108990
- In vitro activation of PDGFR-alpha leads to translational activation of LAMB1, which in turn induces an invasive and metastatic phenotype of hepatocellular carcinoma cells exhibiting K19 expression. PMID: 28783171
- LAMB1 may affect the initiation and progression of pneumoconiosis, or serve as a potential biomarker of pneumoconiosis for diagnosis and genetic susceptibility. PMID: 28444932
- LAMB1 is a potential serological biomarker that could be used in conjunction with carcinoembryonic antigen for diagnosis of colorectal cancer. PMID: 26359947
- These results suggest that MUC5B production can be regulated by ECM components and that MUC5B is upregulated by fibronectin and laminin via the integrin, ERK, and NF-kappaB dependent pathway. PMID: 26057585
- An association was found between LAMB1 rs2158836 polymorphisms and symptom severity in Korean autism spectrum disorder patients. PMID: 25774865
- LAMB1 single nucleotide polymorphism rs886774 was associated with early onset Ulcerative colitis and, thus, suggests a fundamentally different mechanism of early disease pathogenesis in Ulcerative colitis versus Crohn's disease. PMID: 25664710
- Upregulation of LAMB1 expression was highly correlated with the downregulation of miR-124-5p. LAMB1 protein expression was suppressed by miR-124-5p. PMID: 24497408
- The phenotype due to LAMB2 mutations appears to be similar between different ethnic groups. PMID: 23679161
- Homozygous deleterious mutations in LAMB1. PMID: 23472759
- Laminin beta1 and integrin alpha2 expression is elevated in the anterior temporal neocortex tissue from patients with intractable epilepsy. PMID: 21370991
- We did not find an association of rs6949033 (LAMB1) with ulcerative colitis. PMID: 21744425
- mRNA encoding laminin-alpha1, -beta1, and -gamma1 chains was expressed in 90% of endometriotic lesions. PMID: 12615822
- alteration of LAMB1 expression is associated with the genesis and development of uterine leiomyoma PMID: 15706419
- laminin beta1 chain (a constituent of laminin-8) was typically found in vessel walls of carcinomas and their metastases but not in those of normal breast PMID: 15987446
- laminin supports platelet adhesion depending on the interaction of VWF and GPIb-IX-V under pathophysiological high shear flow PMID: 18450753
- Meningiomas increase in size through increased production of extracellular matrix; furthermore, the proliferation of cells typically associated with neoplasia requires considerable interaction with the extracellular matrix. PMID: 18474427
- Elevated expression of laminin beta1 mRNA and protein in the hippocampus suggests that laminin beta1 may play a role in the development of epileptic seizures in patients with intractable epilepsy. PMID: 18691630
- beta2 chain-containing laminins (beta2-laminins) bound more avidly to alpha3beta1 and alpha7X2beta1 integrins than beta1 chain-containing laminins (beta1-laminins). PMID: 19147489
- The presence of nuclear beta-catenin and high content of mmp-9 in the tumor were associated with abnormal accumulation of laminin in the cytoplasm. These changes were characteristic of colorectal cancer with high invasive metastatic potential. PMID: 19526105
- LAMB1 new susceptibility loci for ulcerative colitis PMID: 19915572
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相關疾病：Lissencephaly 5 (LIS5)
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亞細胞定位：Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
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數據庫鏈接：
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