Krt18 Antibody, Biotin conjugated
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中文名稱：Krt18兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA012519LD01MO
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Mus musculus (Mouse) Krt18 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：Krt18 antibody; Kerd antibody; Krt1-18 antibody; Keratin antibody; type I cytoskeletal 18 antibody; Cytokeratin endo B antibody; Keratin D antibody; Cytokeratin-18 antibody; CK-18 antibody; Keratin-18 antibody; K18 antibody
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宿主：Rabbit
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反應種屬：Mouse
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免疫原：Recombinant Mouse Keratin, type I cytoskeletal 18 protein (200-423AA)
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免疫原種屬：Mus musculus (Mouse)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
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基因功能參考文獻：
- K18 deficiency of hepatocytes leads to steatosis, increasing with age, and finally to SH. K18 deficiency and age promote liver tumor development in mice, frequently on the basis of chromosomal instability, resembling human HCC with stemness features. PMID: 27689336
- K8/K18-dependent PKCdelta- and ASMase-mediated modulation of lipid raft size can explain the more prominent FasR-mediated signaling resulting from K8/K18 loss. PMID: 27422101
- autoantibodies were detected in aging K18-null male mice that had a related liver phenotype but normal colon compared with K8-null mice, suggesting that the autoantibodies are linked to liver rather than colonic disease PMID: 26399787
- In human failing myocardium, where TNF-alpha expression is upregulated, K8/K18 were also ectopically expressed PMID: 26280121
- The findings demonstrate the near complete loss of K8/K18 with concomitant high levels of vimentin in CT26 cells, a chemically-induced mouse colonic tumor. PMID: 25882495
- in contrast to its importance as luminal cell marker, CK18 is dispensable for the prostate morphogenesis but contributes to adult prostate regeneration PMID: 24672777
- Keratin 18 increases CFTR expression by binding to its C-terminal hydrophobic domain. PMID: 23045527
- Oxidative stress, Nrf2 and keratin 18 up-regulation associate with Mallory-Denk body formation in mouse erythropoietic protoporphyria PMID: 22334478
- Keratin 8 and keratin 18 mice on the same genetic background show similar sensitivity to DDC intoxication. PMID: 22449798
- These findings reveal the potential for cytokeratin 18 to be used as a diagnostic marker for early detection of hepatosplenic schistosomiasis. PMID: 21357724
- K18 glycosylation provides a unique protective role in epithelial injury by promoting the phosphorylation and activation of cell-survival kinases. PMID: 20729838
- Krt18 may be a useful immunohistochemical marker for detecting hepatocellular proliferative lesions in mice. PMID: 20035116
- Keratin 8 and keratin 18 play roles in regulating the shape and function of mitochondria. PMID: 19825937
- Data show that inhibition of extracellular signal-regulated kinase 1 and 2 (ERK1/2) activation sensitizes wild-type but not keratin 8 (K8)-null mouse hepatocytes to apoptosis, and is associated with a reduction in c-Flip protein, part of a K8/K18 complex. PMID: 15282307
- loss of the keratin cytoskeleton causes defects in the trophoblast giant cell layer PMID: 15819413
- K18 overexpression protects mice from Mallory body (MB) formation and from DDC-induced liver injury, which supports the importance of the K8-to-K18 ratio in MB formation. PMID: 17187412
- Study demonstrates here that, in the developing placenta of the mouse, the absence of the Mrj co-chaperone prevents proteasome degradation of keratin 18 intermediate filaments, resulting in the formation of keratin inclusion bodies. PMID: 17409114
- study shows that dominant mutation hK18 R89C, leads to cell type-specific lethality in mice, depending on ratio of mutant to endogenous keratins; a single, endogenous K18 allele rescued embryonic lethality but caused aggregation of keratins PMID: 17617404
- Keratin absence or mutation is well tolerated after pancreatic but not liver injury, whereas excessive overexpression is toxic to the pancreas but not the liver when induced under basal conditions. PMID: 18349119
- Over expression of K18 R89C predisposes transgenic mice to thioacetamide- but not CCl(4)-induced liver fibrosis. PMID: 18395095
- gene expression of krt8, krt18, and krt19 and correlation with gene expression profiles and cell differentiation are compared in human and mouse embryonic stem cells PMID: 18941637
- Results suggest that the K8/K18 loss induces a switch in Fas-induced death signaling, likely through a DEDD involvement. PMID: 19002587
- Resutls show that the appearance caspase-cleaved CK18 in plasma was found to reflect formation of the caspase-cleaved epitope in PMID: 19407366
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亞細胞定位：Nucleus matrix. Nucleus, nucleolus. Cytoplasm.
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蛋白家族：Intermediate filament family
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組織特異性：Expressed in endoderm, intestinal epithelial cells and in most extraembryonic tissues.
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數據庫鏈接：
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