KMT5B Antibody, FITC conjugated
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中文名稱：KMT5B兔多克隆抗體, FITC偶聯(lián)
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貨號(hào)：CSB-PA674569LC01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) KMT5B Polyclonal antibody
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Uniprot No.：
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基因名：KMT5B
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別名：CGI 85 antibody; CGI85 antibody; Histone-lysine N-methyltransferase KMT5B antibody; Kmt5b antibody; KMT5B_HUMAN antibody; Lysine N-methyltransferase 5B antibody; Lysine-specific methyltransferase 5B antibody; MGC118906 antibody; MGC118909 antibody; MGC21161 antibody; MGC703 antibody; Su(var)4-20 homolog 1 antibody; Suppressor of variegation 4 20 homolog 1 antibody; Suppressor of variegation 4-20 homolog 1 antibody; Suv4-20h1 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Histone-lysine N-methyltransferase KMT5B protein (100-150AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). Plays a role in myogenesis by regulating the expression of target genes, such as EID3. Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4. May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4.
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基因功能參考文獻(xiàn)：
- epsilon-globin expression is regulated by SUV4-20h1. PMID: 26802048
- Altogether, these results reveal Suv4-20h-mediated histone H4K20 tri-methylation as a critical determinant in the selection of active replication initiation sites in heterochromatin regions of mammalian genomes. PMID: 28778956
- overexpression of SUV420H1 may result in activation of the ERK signaling pathway PMID: 26586479
- Strong statistical evidence for a causal role of SUV420H1 in autism. PMID: 26235986
- This study suggests a novel role of FRG1 as epigenetic regulator of muscle differentiation and indicates that Suv4-20h1 has a gene-specific function in myogenesis. PMID: 23720823
- The crystal structure of SUV420H1 was used to characterize substrate selectivity and product specificity. PMID: 24396869
- SUV420H1 and SUV420H2 isoforms have different in their cellular localization and effects on myogenic differentiation PMID: 21206904
- The data indicate that Suv4-20 generates nearly ubiquitous dimethylation that facilitates the DNA damage response and selective trimethylation that is involved in heterochromatin formation.[Suv4-20] PMID: 18296440
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亞細(xì)胞定位：Nucleus. Chromosome.
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蛋白家族：Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, Suvar4-20 subfamily
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數(shù)據(jù)庫(kù)鏈接：
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