KMT2E Antibody

中文名稱：

KMT2E兔多克隆抗體
貨號：

CSB-PA818269LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Hela whole cell lysate, SH-SY5Y whole cell lysate, NIH/3T3 whole cell lysate, 293T whole cell lysate, MCF-7 whole cell lysate, K562 whole cell lysate
All lanes: KMT2E antibody at 3.1μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 205, 196, 69, 99, 186, 181, 201, 132 kDa
Observed band size: 80 kDa
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) KMT2E Polyclonal antibody
Uniprot No.：

Q8IZD2
基因名：

KMT2E
別名：

HDCMC04P antibody; Histone lysine N methyltransferase MLL5 antibody; Histone-lysine N-methyltransferase MLL5 antibody; KMT2E antibody; Lysine N methyltransferase 2E antibody; Lysine N-methyltransferase 2E antibody; MGC70452 antibody; Mll5 antibody; MLL5_HUMAN antibody; Myeloid/lymphoid or mixed lineage leukemia 5 (trithorax homolog; Drosophila) antibody; Myeloid/lymphoid or mixed lineage leukemia 5 antibody; Myeloid/lymphoid or mixed lineage leukemia protein 5 antibody; Myeloid/lymphoid or mixed-lineage leukemia protein 5 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Histone-lysine N-methyltransferase 2E protein (182-316AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，KMT2E Antibody (CSB-PA818269LA01HU)，的標記方式是Non-conjugated。對于KMT2E Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA818269LB01HU	KMT2E Antibody, HRP conjugated	ELISA
FITC	CSB-PA818269LC01HU	KMT2E Antibody, FITC conjugated
Biotin	CSB-PA818269LD01HU	KMT2E Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry. Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition. During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells.; Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity.
基因功能參考文獻：
1. three dimensional structure of MLL5 SET domain unveils the structural basis for its lack of methyltransferase activity PMID: 27812132
2. MLL5 preserves spindle bipolarity through maintaining cytosolic PLK1 in a nonaggregated form. PMID: 27002166
3. MLL5 interacts with OGT and USP7 to form a stable ternary complex. Upregulation of MLL5 expression was correlated with increased expression of OGT and USP7 in human primary cervical adenocarcinomas. PMID: 26678539
4. Suggest a role for MLL5 and H3.3 in maintaining self-renewal hierarchies in adult glioblastomas. PMID: 26626085
5. O-GlcNAcylation of MLL5beta at T440 residue is critical for MLL5 recruitment to the HPV16/18-long control region through its interaction with AP-1. PMID: 25670814
6. Improved outcome is observed in decitabine-treated patients who express MLL5 at high levels. PMID: 24895338
7. KMT2E expression retained association with poor acute promyelocytic leukaemia remission rate and shorter survival while the association with disease-free survival was of marginal significance. PMID: 24796963
8. NMR solution structure of the MLL5 PHD domain PMID: 24130829
9. these results indicate that the suppression of MLL genes, especially MLL2 and MLL5, take part in modulating breast carcinogenesis. PMID: 23754336
10. MLL5 is a cellular ligand for the natural cytotoxicity receptor NKp44. PMID: 23958951
11. findings provide first insights into the molecular basis for the recruitment, exclusion, and regulation of MLL5 at chromatin PMID: 23798402
12. MLL5 can associate with HCF-1 and then be recruited to E2F1-responsive promoters to stimulate H3K4 trimethylation and transcriptional activation. PMID: 23629655
13. A new isoform, MLL5beta, truncated in exon 14, regulates E6 & E7 transcription in cervical carcinoma cells. Interaction of MLL5beta with the AP-1-binding site at the distal region of the HPV18 long control region activated E6/E7 transcription. PMID: 21908553
14. High MLL5 expression levels are associated with a favorable outcome and may improve risk and treatment stratification in acute myeloid leukemia PMID: 21205756
15. Phosphorylation of MLL5 may have an indispensable role in the mitotic progression in mixed lineage leukemia cells. PMID: 20439461
16. MLL5 forms intranuclear protein complexes that may play an important role in chromatin remodeling and cellular growth suppression. PMID: 14718661
17. These findings provide evidence that MLL5 might be an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. PMID: 18573682
18. MLL5 protein has been classified into a distinct subfamily with SETD5, because its SET domain and domain architecture show high homology with SETD5 rather than the members in MLL subfamily (i.e. MLL, MLL2, MLL3 and MLL4) PMID: 18231586
19. MLL5 is a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia. PMID: 12101424
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亞細胞定位：

Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus speckle.; [Isoform 3]: Nucleus, nucleoplasm. Nucleus speckle.; [Isoform NKp44L]: Cytoplasm. Cell membrane; Peripheral membrane protein.
蛋白家族：

Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, TRX/MLL subfamily
組織特異性：

Widely expressed in both adult and fetal tissues. Highest levels of expression observed in fetal thymus and kidney and in adult hematopoietic tissues, jejunum and cerebellum. Isoform NKp44L: Not detected on circulating cells from healthy individuals, but
數據庫鏈接：

HGNC: 18541

OMIM: 608444

KEGG: hsa:55904

STRING: 9606.ENSP00000257745

UniGene: Hs.592262

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