KLF8 Antibody

說明書

中文名稱：

KLF8兔多克隆抗體
貨號：

CSB-PA006805
規格：

￥1090
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

O95600
基因名：

KLF8
別名：

Basic krueppel-like factor 3 antibody; BKLF3 antibody; DXS741 antibody; KLF8 antibody; KLF8_HUMAN antibody; Krueppel-like factor 8 antibody; Kruppel like factor 8 antibody; MGC138314 antibody; Zinc finger protein 741 antibody; ZNF741 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from the Internal region of Human KLF8.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:10000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK).
基因功能參考文獻：
1. High KLF8 expression is associated with breast cancer cell invasion, transendothelial migration and metastasis. PMID: 26993780
2. expression of miR-1236-3p was lower in lung adenocarcinoma tissues than that in adjacent normal tissue; in A549 cell line, miR-1236-3p decreased ability of cell invasion and migration; furthermore, KLF8 is targeted by miR-1236-3p, and expression of miR-1236-3p is negatively correlated with KLF8; additionally, miR-1236-3p suppressed the expression of KLF8 and EMT (epithelial mesenchymal transition)-related genes PMID: 28842254
3. Overexpression of KLF8 may contribute to the progression of pancreatic cancer, and downregulation of KLF8 expression by lentivirus-delivered shRNA is a novel therapeutic approach for PC. PMID: 26995652
4. KLF8 plays a crucial role in proliferation and migration of bladder cancer cells PMID: 25323066
5. KLF8-induced FHL2 activation is a novel and critical signaling mechanism underlying human colorectal cancer invasion and metastasis. PMID: 26320172
6. KLF8 and miR141/EGFR have roles in signaling pathway potentially crucial for breast cancer malignancy PMID: 26025929
7. KLF8 suppression induced cell differentiation and inhibited tumorigenesis in colorectal cancer PMID: 26133391
8. MiR-135a inhibits migration and invasion and regulates epithelial-mesenchymal transition-related marker genes by targeting KLF8 in lung cancer cells. PMID: 26235874
9. KLF8 is a novel epithelial to mesenchymal transition regulating transcription factor that involved in the progression of gastric cancer. PMID: 25333643
10. In this review, we focus on the functions, roles, and regulatory networks of these five KLFs in HCC, summarize key pathways, and propose areas for further investigation PMID: 25652467
11. A novel KLF8 to EPSTI1 to VCP to NF-kappaB signaling mechanism potentially critical for breast cancer invasion and metastasis. PMID: 24096480
12. KLF8 is involved in hypoxia-induced multidrug resistance through inhibiting apoptosis and increasing the drug release rate by directly regulating MDR1 transcription. PMID: 25040744
13. Positive nuclear KLF8 might be correlated with lower survival in gastric adenocarcinoma patients and might be an oncogene property in gastric adenocarcinoma carcinogenesis. PMID: 24461703
14. KLF8 knockdown suppresses proliferation and invasion in human osteosarcoma cells. PMID: 24604387
15. KLF8 and FAK cooperatively enrich the active MMP14 on the cell surface required for the metastatic progression of breast cancer. PMID: 23812425
16. Hypoxia-reoxygenation reduces the expression and nuclear localization of KLF8 to inhibit the trophoblast invasion by downregulating MMP-9 levels. PMID: 23703536
17. KLF8 overexpression is an important factor in human ovarian carcinoma pathogenesis. PMID: 23222713
18. KLF8 is closely associated with gastric tumor progression, angiogenesis and poor prognosis PMID: 23885141
19. High KLF8 methylation was associated with biochemical recurrence in prostate cancer. PMID: 23918943
20. With pull down assay and co-immunoprecipitation assay, the study demonstrated that KLF8 bound directly to AR, and KLF8 enhanced AR target gene transcription in human prostate cancer cells. PMID: 23023312
21. Data show that TGF-beta1 regulates E-cadherin and vimentin expression through KLF8 pathway. PMID: 23504025
22. a novel role and mechanism for KLF8 in the regulation of DNA repair and therapeutic resistance in breast cancer cells. PMID: 23105099
23. KLF8 is necessary for cell survival and invasion in gastric cancer cells. PMID: 22766838
24. Knockdown of beta-catenin by shRNA rescues the enhanced HepG2 and Hep3B cells proliferation ability induced by overexpression of KLF8 PMID: 22761862
25. Kruppel-like factor 8 (KLF8) is expressed in gliomas of different WHO grades and is essential for tumor cell proliferation. PMID: 22276196
26. PARP-1 as a novel KLF8-binding and -regulating protein and provided new insights into the mechanisms underlying the regulation of KLF8 nuclear localization, stability, and functions. PMID: 21518760
27. Immunohistochemical staining strongly correlated the co-expression of KLF8 and MMP9 with the patient tumor invasion, metastasis and poor survival PMID: 21151179
28. KLF8 promotes hepatocellular carcinoma cell proliferation and invasion, inhibits apoptosis, and induces the epithelial-to-mesenchymal transition PMID: 20728449
29. KLF8 is possibly involved in regulating cell growth, invasion, apoptosis, and proliferation of renal carcinoma cancer; blocking this protein may be a therapeutic strategy for this cancer. PMID: 20182889
30. The gene KLF8 is abnormally expressed in a female patient with X;autosome translocation t(X;21)(p11.2;q22.3) and non-syndromic mental retardation. PMID: 11836360
31. Over expression of KLF8 is associated with cancer PMID: 16832343
32. Functional studies using RNA interference revealed that the silencing of Sp1 and KLF8 resulted in elevated level of gamma globin expression in K562 cells. PMID: 17224162
33. Overexpression of Kruppel-like factor 8 is associated with epithelial to mesenchymal transition and epithelial cell invasion leading to breast cancer PMID: 17671186
34. FAK induces KLF8 expression in human ovarian cancer cells by activating the PI3K-Akt signaling pathway, leading to the activation of KLF8 promoter by Sp1 PMID: 18353772
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亞細胞定位：

Nucleus.
蛋白家族：

Sp1 C2H2-type zinc-finger protein family
組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 6351

OMIM: 300286

KEGG: hsa:11279

STRING: 9606.ENSP00000417303

UniGene: Hs.646614

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