KLF11 Antibody

說明書

中文名稱：

KLF11兔多克隆抗體
貨號：

CSB-PA004290
規格：

￥1090
圖片：
Western Blot analysis of HuvEc cells using TIEG2 Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

O14901
基因名：

KLF11
別名：

9830142A17 antibody; D12Ertd427e antibody; FKLF antibody; FKLF1 antibody; Klf11 antibody; KLF11_HUMAN antibody; Krueppel like factor 11 antibody; Krueppel-like factor 11 antibody; Krueppel-like transcription factor 1 antibody; MODY7 antibody; Tcfcp2l2 antibody; TGFB Early Growth Response 2 antibody; TGFB-inducible early growth response protein 2 antibody; TGFB-inducible early growth response protein 2b antibody; TGFB-inducible early growth response protein 3 antibody; TIEG 2 antibody; TIEG-2 antibody; TIEG-3 antibody; Tieg2b antibody; Transforming Growth Factor Beta Inducible Early Growth Response 2 antibody; Transforming growth factor-beta-inducible early growth response protein 2 antibody; Transforming growth factor-beta-inducible early growth response protein 3 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from the N-terminal region of Human TIEG2.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IHC, IF, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
IF	1:200-1:1000
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis.
基因功能參考文獻：
1. Profibrotic gene expression was activated in a primary human peritoneal cell line in response to KLF11 short hairpin RNA and medroxyprogesterone acetate but not estradiol. PMID: 28938437
2. In endometrial-stromal fibroblasts, KLF11 recruited SIN3A/HDAC (histone deacetylase), resulting in COL1A1-promoter deacetylation and repression PMID: 26935598
3. Results suggest a role for KLF11 in upregulating MAO-A in depressive disorder and chronic social stress, suggesting that inhibition of the pathways regulated by this transcription factor may aid in the therapeutics of neuropsychiatric illnesses PMID: 25502632
4. The data suggest a relationship between promoter DNA methylation and KLF11 gene expression in ovarian cancer tumorigenesis. PMID: 25931269
5. identified an evolutionarily conserved metabolic regulator, Kruppel-like factor 11 (KLF11), as a novel browning transcription factor in human adipocytes that is required for rosiglitazone-induced browning. PMID: 25504365
6. KLF11 repressed most endometrial CYP enzymes PMID: 25076120
7. Levels of KLF11 are significantly increased in the postmortem prefrontal cortex of subjects with alcohol dependence compared to controls. PMID: 23915421
8. KLF11 regulates distinct gene networks. PMID: 24885560
9. KLF111 represses glycodelin-A levels and influences its role in the ovarian endometrium. PMID: 24060634
10. KLF11 is a critical transcription factor in the function of mesenchymal cells and, specifically, as a negative regulator of collagen secretion. PMID: 24069400
11. Data identify a novel pathogenic role for KLF11 in preventing de novo disease-associated fibrosis in endometriosis. PMID: 23555910
12. The A347S mutation disrupted KLF11-mediated increases in basal insulin levels and promoter activity and blunted glucose-stimulated insulin secretion. PMID: 23589285
13. Data indicate that median methylation levels of BCAN, HOXD1, KCTD8, KLF11, NXPH1, POU4F1, SIM1, and TCF7L1 were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis. PMID: 22930747
14. KLF11 has a role in fine-tuning insulin transcription in certain cellular situations rather than representing a major transcriptional activator or repressor of the insulin gene. PMID: 22801105
15. Kruppel-like factor-11, a transcription factor involved in diabetes mellitus, suppresses endothelial cell activation via the nuclear factor-kappaB signaling pathway. PMID: 23042817
16. KLF11 is an MAO A regulator and is produced in response to neuronal stress, which transcriptionally activates MAO A. PMID: 22628545
17. Here we report the characterization of two antagonistic, chromatin-mediated mechanisms by which KLF11 regulated the transcription of the dopamine D2 receptor. PMID: 22375010
18. A PXVXL HP1-interacting domain identified at position 487-491 of KLF11 mediates the binding of HP1alpha and KLF11 in vitro and in cultured cells. PMID: 22318730
19. an important role for KLF11 in the regulation of INS transcription via the novel c.-331 KLF site. PMID: 21592955
20. epigenetic inactivation and subsequent transcriptional repression of the KLF11 gene is quite frequent in MDS. PMID: 20002157
21. Kruppel-like factor 11 has a role in the regulation of prostaglandin E2 biosynthesis PMID: 20154088
22. KLF11 is an integrator of progesterone receptor signaling and proliferation in uterine leiomyoma cells. PMID: 20124487
23. TIEG2 is an activator of Monoamine oxidase B gene expression. PMID: 15024015
24. novel mechanism in TGF-beta-regulated gene expression: KLF11 potentiates Smad-signaling activity in normal epithelial cells through termination of the negative feedback loop imposed by Smad7. PMID: 15300592
25. in the presence of cholesterol, KLF11 acts as a dominant repressor of the caveolin-1 gene PMID: 15531587
26. KLF11 plays a role in the regulation of pancreatic beta cell physiology, and its variants may contribute to the development of diabetes. PMID: 15774581
27. These results suggest a central role for KLF11 in TGFbeta-induced c-myc repression and antiproliferation. PMID: 17114344
28. KLF11 A347S and T220M mutations do not contribute to increased risk of diabetes in European-derived populations. PMID: 17130512
29. results may help to increase the understanding of Tieg3-mediated transcriptional control and to characterize this TGF-beta-induced Sp1/Klf-like transcription factor PMID: 17252542
30. TIEG2 decreases the levels of the anti-apoptotic protein Bcl-X(L) and inhibits transcription driven by the Bcl-X(L) promoter. PMID: 17308981
31. Kruppel-like factor 11 inhibits human proinsulin promoter activity in pancreatic beta cells PMID: 17479246
32. KLF11 may interfere with glucose homeostasis in a Danish general population and that STAT3-mediated up-regulation of KLF11 transcription was impaired by the -1659G>C variant. PMID: 18505768
33. KLF11 is unlikely to play a major role in the etiology of T2 diabetes among this Native American population. PMID: 18593768
34. 19 polymorphisms, 6 of which are novel, were identified, but none of them showed association with type 2 diabetes. Functional analyses of these variants showed reduced effects on transcriptional activities of insulin, catalase1, & the Smad7 gene. PMID: 19122346
35. MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cells. PMID: 19843526
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相關疾病：

Maturity-onset diabetes of the young 7 (MODY7)
亞細胞定位：

Nucleus.
蛋白家族：

Sp1 C2H2-type zinc-finger protein family
組織特異性：

Ubiquitous. Higher expression in erythroid cells.
數據庫鏈接：

HGNC: 11811

OMIM: 603301

KEGG: hsa:8462

STRING: 9606.ENSP00000307023

UniGene: Hs.12229

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