KIR3DS1 Antibody, HRP conjugated

說明書

中文名稱：

KIR3DS1兔多克隆抗體, HRP偶聯
貨號：

CSB-PA614817LB01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) KIR3DS1 Polyclonal antibody
Uniprot No.：

Q14943
基因名：

KIR3DS1
別名：

KIR3DS1 antibody; NKAT10Killer cell immunoglobulin-like receptor 3DS1 antibody; MHC class I NK cell receptor antibody; Natural killer-associated transcript 10 antibody; NKAT-10 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Killer cell immunoglobulin-like receptor 3DS1 protein (198-335AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Receptor on natural killer (NK) cells for MHC class I molecules. Upon interaction with peptide-free HLA-F open conformer, triggers NK cell degranulation and anti-viral cytokine production.
基因功能參考文獻：
1. interactions between KIR3DS1 and HLA-F contribute to NK cell-mediated control of HCV. PMID: 30031767
2. The combination of KIR3DS1 with homozygosity for HLA-Bw4 alleles (the putative ligand for KIR3DS1) was significantly less frequent in the HIV-1 infected group than in the control group PMID: 29664957
3. Furthermore, the KIR3DS1 + HLA-Bw4, KIR3DS1 + HLA-Bw4 (Iso80) , and KIR3DS1 + HLA-A Bw4 genotypes were significantly more common in recovered individuals than both healthy control and patient groups. PMID: 29032460
4. KIR3DS1*01301, 3DL1*00401, and 3DL1*00402 showed susceptibility and elevated mRNA expression and is associated with antibody mediated acute rejection and chronic rejection. PMID: 28942035
5. Study assessed which of the TB01 encoded KIR gene products contributed to Natural Killer cell responsiveness; of the TB01 KIR gene products examined, only KIR3DS1 conferred responsiveness to HLA-null stimulation, demonstrating its ligation can activate ex vivo Natural Killer cells. PMID: 28938026
6. genetic polymorphism is not related to acute myeloid leukemia in Chinese population PMID: 25636577
7. The data from this study contribute novel insight into how KIR3DS1-specific polymorphisms in the extracellular region impact KIR3DL1 surface expression, ligand binding, and inhibitory function. PMID: 26109640
8. Data suggest that low level of activating KIR3DS1 and its combination with HLA-B Bw4Ile80 ligand might have an influence on the susceptibility to tuberculosis (TB) in Lur population of Iran. PMID: 22426166
9. KIR3DS1, in addition to HLA-B27, may play an important independent role in the pathogenesis of ankylosing spondylitis in the Chinese population. PMID: 22744805
10. Results show that the KIR3DS1 genotype has a positive effect on HCV viral clearance during the first weeks of Peg-IFN/RBV treatment in HCV/HCV co-infected patients bearing genotype 1, and higher RVR and SVR rates. PMID: 23613999
11. results suggest that the sole presence of KIR3DS1 could have a protective role in HIV-1 infection in highly exposed and persistently seronegative individuals PMID: 23789883
12. There is evidence of the association of activating KIR genotypes with an increased risk for autoimmune disease PMID: 21779711
13. Our results that KIR2DL5 and KIR3DS1 may have a predisposing role in multiple sclerosis PMID: 21665278
14. These data provide the first evidence for the direct binding of KIR3DS1(+) cells to HLA-Bw4 and highlight the key role for position 138 in determining ligand specificity of KIR3DS1 PMID: 21804024
15. The most significant difference in PFS observed in multiple myeloma patients after autologous stem cell transplantation was with those with GR KIR3DS1(+) in whom HLA-Bw4, the ligand for the corresponding inhibitory receptor KIR3DL1, was missing PMID: 20562327
16. The increased frequency of the KIR3DS1*013 allele in patients with amnkylosing spondylitis is clearly independent of the presence of the HLA-Bw4I80 epitope. PMID: 20131260
17. Compared with KIR3DS1(-) donors, donor KIR3DS1 was associated with lower-grade II-IV acute graft-versus-host disease. PMID: 20124216
18. Carriage of activating 3ds1 was increased in patients with herpes virus RDs. PMID: 17592337
19. Sequencing analysis identified a variant with a complex deletion/substitution mutation in exon 4 (which encodes the D1 extracellular domain), resulting in a premature stop codon and might affect its expression and activating capacity PMID: 17687550
20. Variation at the KIR locus influences the effectiveness of NK cell activity in the containment of viral replication. PMID: 18025129
21. We observed that possessing KIR3DS1 was associated with higher NK cell effector functions in early HIV-1 disease, despite the absence of HLA Bw4Ile80, a putative ligand of KIR3DS1. PMID: 18305035
22. KIR3DS1 expression on NK cells can be induced after exposure to stimulator cells PMID: 19454667
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亞細胞定位：

Cell membrane; Single-pass type I membrane protein.
蛋白家族：

Immunoglobulin superfamily
組織特異性：

Expressed in NK and T-cell lines but not in B-lymphoblastoid cell lines or in a colon carcinoma cell line.
數據庫鏈接：

HGNC: 6340

OMIM: 604946

KEGG: hsa:3813

STRING: 9606.ENSP00000375608

UniGene: Hs.645228

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