KIN Antibody
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中文名稱：KIN兔多克隆抗體
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貨號(hào)：CSB-PA012351GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：KIN
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別名：KIN antibody; BTCD antibody; KIN17DNA/RNA-binding protein KIN17 antibody; Binding to curved DNA antibody; KIN antibody; antigenic determinant of recA protein homolog antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Human KIN
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo. Binds via its C-terminal domain to RNA in vitro.
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基因功能參考文獻(xiàn)：
- Findings demonstrate that kin17 is closely related to the cell proliferation and invasion of cervical cancer. PMID: 28346239
- overexpression of KIN rendered colorectal cancer cells enriching cancer stem cell (CSC) markers and CSC phenotype, and silencing KIN reduced CSC markers and CSC phenotype. PMID: 24755081
- Trimethylated at Lys-135 by METTL22 PMID: 23349634
- up-regulation of kin17 is strongly associated with cellular proliferation, DNA replication, DNA damage response and breast cancer development PMID: 21980430
- ionizing radiation triggers chromatin complex formation in human cells PMID: 11880372
- The overexpression of human kin17 protein in vivo and the introduction of increased amounts of human kin17 protein in an in vitro assay reduced T-antigen-dependent DNA replication. PMID: 12359749
- results indicate the presence of functional XPA and XPC proteins is essential for the up-regulation of the KIN17 gene after UVC irradiation; also show that the integrity of global genome repair is required to trigger KIN17 gene expression PMID: 12525703
- KIN17 protein may be a component of the DNA replication machinery that participates in the cellular response to unrepaired DSBs, and an impaired KIN17 pathway leads to an increased sensitivity to ionizing radiation. PMID: 12751957
- A chromatin-associated protein conserved during evolution and overproduced in certain human tumor cell lines, which is involved in DNA replication. PMID: 12754299
- Kin17 protein strongly associates in vivo with DNA fragments containing replication origins in both human HeLa and monkey CV-1 cells. PMID: 15831485
- C-terminal domain of human KIN17 has a basic pI, heavy-atom derivatives were obtained by soaking crystals with negatively charged ions such as tungstate & iodine. Replacement of LiCl by KI in cryosolution allowed determination of phases from iodide ions. PMID: 16511313
- Analysis of KIN17 structure complexed with tungstate shows structural variability within the domain PMID: 17045609
- Thus, human KIN17 region 51-160 might rather be involved in protein-protein interaction through its conserved surface centered on the 3(10)-helix. PMID: 18029424
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亞細(xì)胞定位：Nucleus. Cytoplasm.
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蛋白家族：KIN17 family
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組織特異性：Ubiquitously expressed in all tissues examined, with highest levels in skeletal muscle, heart and testis. Differentially expressed in non-tumorigenic and tumorigenic cell lines. Highly expressed in proliferating epithelial keratinocyte cells in vitro (at
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數(shù)據(jù)庫(kù)鏈接：
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