KIF1B Antibody

說明書

中文名稱：

KIF1B兔多克隆抗體
貨號：

CSB-PA012319ESR1HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA012319ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA012319ESR1HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) KIF1B Polyclonal antibody
Uniprot No.：

O60333
基因名：

KIF1B
別名：

KIF1B antibody; KIAA0591 antibody; KIAA1448Kinesin-like protein KIF1B antibody; Klp antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Kinesin-like protein KIF1B protein (1547-1816AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility. Isoform 2 is required for induction of neuronal apoptosis.; Isoform 1 mediates the transport of synaptic vesicles in neuronal cells.
基因功能參考文獻：
1. In conclusion, using a panel including 17 susceptibility genes, we documented the presence of somatic mutations in over 50% of pheochromocytomas and paragangliomas (PPGL). We confirmed the high frequency of NF1 somatic mutations and identified KIF1B as the second most frequently mutated gene in PPGL tissues. PMID: 28515046
2. The rs17401966 polymorphism reduced the risk for HCC under the allele, heterozygous, homozygous, and dominant models but not under the additive or recessive models. PMID: 28427253
3. BORC and Arl8 function upstream of two structurally distinct kinesin types: kinesin-1 (KIF5B) and kinesin-3 (KIF1Bbeta and KIF1A). PMID: 27851960
4. The gene-environment interaction between the KIF1B rs17401966 variant and alcohol consumption may contribute to the development of hepatocellular carcinoma in Chinese individuals. PMID: 27122668
5. Increased KIF1B was associated with worse WHO pathological classification, Karnofsky performance status, and prognosis. Silencing KIF1B inhibited expression of membranal MT1-MMP. PMID: 26576027
6. Downregulation of KIF1B in hepatocellular carcinoma tissues is associated with poor prognosis. PMID: 26217094
7. the rs17401966 polymorphism likely regulates KIF1B mRNA expression and thus may be associated with epithelial ovarian cancer risk in Eastern Chinese women. PMID: 25854172
8. The tumor suppressor DLC2 and Kif1B are central components of a signaling network that guides spindle positioning, cell-cell adhesion and mitotic fidelity. PMID: 25518808
9. Results from targeted sequencing in patients with acute lymphoblastic leukemia identified KMT2D and KIF1B as novel putative driver genes and a putative regulatory non-coding variant that coincided with overexpression of the growth factor MDK. PMID: 25355294
10. The variant G allele of rs17401966 may be a favorable biomarker for the prognosis of intermediate or advanced hepatitis B virus-related hepatocellular carcinoma patients in this Chinese population PMID: 25153661
11. the KIF1B gene SNP (rs174019660) showed no significant association with HBV-related hepatocellular carcinoma in Thai patients infected with HBV, indicating that there must be other mechanisms or pathways involved in hepatocellular carcinoma. PMID: 23803045
12. The meta-analysis showed a significant association between kinesin family member 1B (KIF1B) single nucleotide polymorphism (rs17401966) and hepatocellular carcinoma (HCC). PMID: 24952890
13. Results show that KIF1Bbeta has neuroblastoma tumor-suppressor properties and promotes and requires nuclear-localized DHX9 for its apoptotic function by activating XAF1 expression. PMID: 24469107
14. KIF1B may play a critical role in the development of hepatocellular carcinoma PMID: 23634229
15. Leptin, MT1-MMP and KIF1B are overexpressed in GC tissues. PMID: 23354307
16. the TT genotype of rs1535045 was associated with a slower progression of MS and early MS onset. PMID: 23528589
17. activity-dependent synaptic recruitment of KIF1Bbeta, its interaction with Ca(2 ) sensor Calmodulin and its role as a dendritic motor of ribonucleoprotein complexes provide a novel basis for understanding the coordination of motor protein mobilization and synaptic signaling pathways PMID: 22945799
18. Polymorphisms at KIF1B gene locus investigated in this study showed no significant association with Hepatitis B virus infection. PMID: 23028799
19. This study showed the new locus identified for hepatocellular carcinoma, KIF1B, was not associated with progression to chronic hepatitis B. PMID: 22363396
20. No association is found between rs10492972 KIF1B polymorphism and the progression of multiple sclerosis in Greek subjects. PMID: 21424745
21. Polymorphic locus rs10492972 of the KIF1B gene associates with multiple sclerosis in Russia. PMID: 21680216
22. analysis of the KIF1B rs10492972*C allelic association in multiple sclerosis PMID: 21594895
23. Data show that no evidence could be found for a determining influence of carriership of the risk allele or genotype of the KIF1B gene on any of the multiple sclerosis neurodegenerative phenotypic markers studied. PMID: 21606458
24. KIF1B rs10492972 allelic variant does not act as a risk factor as well as a disease modifier in a Italian cohort of patients with progressive relapsing multiple sclerosis. PMID: 20067515
25. Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma. PMID: 20190806
26. KIF1Ba in addition to KIF1Bbeta may not be a candidate tumor suppressor gene for neuroblastoma PMID: 12888911
27. KBP is a new binding partner for KIF1Balpha that is a regulator of its transport function and thus represents a new type of kinesin interacting protein. PMID: 16225668
28. We detected ALS-specific down-regulation of KIF1Bbeta and novel KIF3Abeta, two isoforms we show to be enriched in the brain, and also of SOD1, a key enzyme linked to familial ALS. PMID: 17418584
29. Study identified inherited loss-of-function KIF1Bbeta missense mutations in neuroblastomas and pheochromocytomas and an acquired loss-of-function mutation in a medulloblastoma. PMID: 18334619
30. KIF1Bbeta may act as a haploinsufficient tumor suppressor, and its allelic loss may be involved in the pathogenesis of neuroblastoma and other cancers. PMID: 18614535
31. a germline mutation in the KIF1B beta gene on 1p36 may have a role in neural and nonneural tumors PMID: 18726616
32. Study reports a genome wide association study identifying a new locus replicated in 2,679 cases and 3,125 controls; an rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 x 10(-10)). PMID: 18997785
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相關疾?。?/div>
Charcot-Marie-Tooth disease 2A1 (CMT2A1); Neuroblastoma 1 (NBLST1); Pheochromocytoma (PCC)
亞細胞定位：

Cytoplasm, cytoskeleton. Mitochondrion. Cell projection, axon.; [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.
蛋白家族：

TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, Unc-104 subfamily
組織特異性：

Isoform 3 is abundant in the skeletal muscle. It is also expressed in fetal brain, lung and kidney, and adult heart, placenta, testis, ovary and small intestine. Isoform 2 is abundant in the brain and also expressed in fetal heart, lung, liver and kidney,
數據庫鏈接：

HGNC: 16636

OMIM: 118210

KEGG: hsa:23095

STRING: 9606.ENSP00000263934

UniGene: Hs.97858

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