KIAA0226L Antibody
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中文名稱：KIAA0226L兔多克隆抗體
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貨號(hào)：CSB-PA003112GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：RUBCNL
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別名：C13orf18 antibody; CM018_HUMAN antibody; FLJ21562 antibody; FLJ43762 antibody; KIAA0226 like antibody; KIAA0226L antibody; RP11-247M1.4 antibody; Uncharacterized protein C13orf18 antibody; Uncharacterized protein KIAA0226-like antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Human C13orf18
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB,IHC,IF
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy. Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex. Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes. Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P). In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis. May act as a tumor suppressor.
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基因功能參考文獻(xiàn)：
- Pacer localizes to autophagic structures and positively regulates autophagosome maturation. PMID: 28306502
- Re-activation of C13ORF18 led to partial demethylation of the C13ORF18 promoter and decreased repressive histone methylation. PMID: 23522960
- Data suggest that the four-gene methylation panel might provide an alternative triage test after primary high-risk papillomavirus (hr-HPV) testing. PMID: 21796628
- Methylation of C13orf18 in cervical scrapings is strongly associated with high-grade cervical intraepithelial neoplasia and cervical cancer. PMID: 19843677
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亞細(xì)胞定位：Cytoplasmic vesicle, autophagosome membrane; Peripheral membrane protein.
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組織特異性：Expressed weakly in cervical carcinoma cell lines.
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數(shù)據(jù)庫(kù)鏈接：
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