KCNK16 Antibody

中文名稱：

KCNK16兔多克隆抗體
貨號：

CSB-PA850434LA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA850434LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA850434LA01HU at dilution of 1:100
其他：

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) KCNK16 Polyclonal antibody
Uniprot No.：

Q96T55
基因名：

KCNK16
別名：

KCNK16; TALK1; Potassium channel subfamily K member 16; 2P domain potassium channel Talk-1; TWIK-related alkaline pH-activated K(+ channel 1; TALK-1
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Potassium channel subfamily K member 16 protein (259-309AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產(chǎn)品，KCNK16 Antibody (CSB-PA850434LA01HU)，的標記方式是Non-conjugated。對于KCNK16 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產(chǎn)品名稱	應用
HRP	CSB-PA850434LB01HU	KCNK16 Antibody, HRP conjugated	ELISA
FITC	CSB-PA850434LC01HU	KCNK16 Antibody, FITC conjugated
Biotin	CSB-PA850434LD01HU	KCNK16 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.
基因功能參考文獻：
1. data establish TALK-1 channels as key regulators of beta cell ER Ca(2+) and suggest that TALK-1 may be a therapeutic target to reduce ER Ca(2+) handling defects in beta cells during the pathogenesis of diabetes. PMID: 28928238
2. The TALK-1/iOPN complex caused Vm hyperpolarization and reduced beta-cell glucose-stimulated Ca2+ influx, which is predicted to inhibit glucose stimulated insulin secretion. PMID: 28403169
3. These findings reveal TALK-1 channels as important modulators of second-phase insulin secretion and suggest a clinically relevant mechanism for rs1535500, which may increase type 2 diabetes risk by limiting glucose-stimulated insulin secretion. PMID: 26239056
4. at least two functional TALK-1 variants are present and may serve as background K+ currents in certain cells of the human pancreas. PMID: 12724142
亞細胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

Two pore domain potassium channel (TC 1.A.1.8) family
組織特異性：

Highly expressed in pancreas. Not detectable in the other tissues tested.
數(shù)據(jù)庫鏈接：

HGNC: 14464

OMIM: 607369

KEGG: hsa:83795

STRING: 9606.ENSP00000391498

UniGene: Hs.287765

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