KCNJ4 Antibody

說明書

中文名稱：

KCNJ4兔多克隆抗體
貨號：

CSB-PA012057ESR1HU
規格：

￥440
圖片：
Western blot
All lanes: KCNJ4 antibody at 2.04µg/ml
Lane 1: Hela whole cell lysate
Lane 2: 293T whole cell lysate
Lane 3: HepG2 whole cell lysate
Lane 4: Jurkat whole cell lysate
Lane 5: MCF-7 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 50 kDa
Observed band size: 50 kDa

Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA012057ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA012057ESR1HU at dilution of 1:100
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靶點詳情

產品詳情

產品描述：

The KCNJ4 antibody is designed to recognize the human KCNJ4 protein. When a rabbit received an injection of the recombinant human KCNJ4 protein, an immune response occurred in the rabbit producing large amounts of antibodies against the KCNJ4 protein. The rabbit's blood was collected and isolated to get the anti-serum, which was antigen affinity purified to obtain the KCNJ4 polyclonal antibody.

This KCNJ4 antibody has accessed its specificity for the human KCNJ4 protein in ELISA, WB, and IHC applications. KCNJ4 mainly regulates the flow of potassium ions across the cell membrane of cardiac myocytes. It also participates in the modulation of the heart rate and cardiac output.
產品名稱：

Rabbit anti-Homo sapiens (Human) KCNJ4 Polyclonal antibody
Uniprot No.：

P48050
基因名：

KCNJ4
別名：

KCNJ4; IRK3; Inward rectifier potassium channel 4; HIRK2; HRK1; Hippocampal inward rectifier; HIR; Inward rectifier K(+ channel Kir2.3; IRK-3; Potassium channel, inwardly rectifying subfamily J member 4
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Inward rectifier potassium channel 4 protein (316-445AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium.
基因功能參考文獻：
1. Increased excitability and decreased dendritic arborization are associated with downregulation of inward rectifier potassium channels (Kir2.1/2.3). PMID: 22396414
2. Kir2.3 is internalized by an AP-2 clathrin-dependent mechanism. PMID: 18180291
3. possibility of intramolecular interactions of the residue Kir2.3(H117) with conserved cysteines in close proximity to the selectivity filter PMID: 18453743
4. The data suggest that Kir2.3 plays a potentially important role in I(K1) currents in neonatal rat cardiomyocytes. PMID: 18503768
5. TIP-1 may act as an important regulator for the endocytic pathway of Kir2.3. PMID: 19635485
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亞細胞定位：

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane.
蛋白家族：

Inward rectifier-type potassium channel (TC 1.A.2.1) family, KCNJ4 subfamily
組織特異性：

Heart, skeletal muscle, and several different brain regions including the hippocampus.
數據庫鏈接：

HGNC: 6265

OMIM: 600504

KEGG: hsa:3761

STRING: 9606.ENSP00000306497

UniGene: Hs.32505

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