KCNIP4 Antibody, HRP conjugated
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中文名稱：KCNIP4兔多克隆抗體, HRP偶聯
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貨號：CSB-PA750882LB01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) KCNIP4 Polyclonal antibody
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Uniprot No.：
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基因名：KCNIP4
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別名：A type potassium channel modulatory protein 4 antibody; A-type potassium channel modulatory protein 4 antibody; CALP antibody; Calsenilin like protein antibody; Calsenilin-like protein antibody; HGNC:30083 antibody; KCHIP 4 antibody; KChIP4 antibody; KCIP4_HUMAN antibody; KCNIP 4 antibody; Kcnip4 antibody; Kv channel interacting protein 4 antibody; Kv channel-interacting protein 4 antibody; MGC44947 antibody; Potassium channel interacting protein 4 antibody; Potassium channel-interacting protein 4 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Kv channel-interacting protein 4 protein (1-250AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND3/Kv4.3 currents. Isoform 4 does not increase KCND2 expression at the cell membrane. Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane.
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基因功能參考文獻：
- Results indicate that SNPs in KCNIP4 may modulate ACE inhibitor-induced cough risk. PMID: 26169577
- Subunit counting by single-molecule imaging revealed that the bound number of KChIP4 in each Kv4.2.KChIP4 complex was dependent on the expression level of KChIP4. PMID: 24811166
- genetic association studies in populations in Germany: Data suggest that multiple SNPs in KCNIP4 are associated not only with attention deficit disorder with hyperactivity in children and adults but also with personality disorders. PMID: 22981920
- Genome-wide association study identifies KCNIP4 as an asthma gene in human and in mouse. PMID: 23457522
- KChIP4a suppresses A-type Kv4 current via ER retention and enhancement of Kv4 closed-state inactivation. PMID: 23576435
- The synthesis of the variant KCNIP4 isoform is also detrimental to brain physiology, as it results in the concomitant blockade of the fast kinetics of potassium channels. PMID: 21624954
- These data demonstrate that PKA phosphorylation of Kv4.2 plays an important role in the trafficking of Kv4.2 through its specific interaction with KChIP4a. PMID: 20045463
- cloning and investigation of interaction with presenilin 2 and voltage-gated potassium channel subunit Kv4 PMID: 11847232
- The conformational change with metal-bound KChIP4.1 is crucial for its interaction with Kv channel but not for KChIP2.2, and that the Mg2+- and Ca2+-binding properties of KChIP2.2 and KChIP4.1 have different effects on their molecular structure. PMID: 16951992
- Mutation of KCNIP4 is associated with renal cell carcinoma. PMID: 17981209
- CALP and calsenilin are involved in the trafficking of Golgi glycosyltransferases. PMID: 18269347
- These results reveal a new role for KChIP3 in the regulation of calcium regulated secretion and also suggest that the functions of each of the KChIPs may be more specialized than previously appreciated. PMID: 18393943
- KChIP4a, KChIP2x, and KChIP3x comprise a novel class of KChIP isoforms characterized by an unusual transmembrane domain at their N termini that modulates Kv4 channel gating and trafficking. PMID: 18957440
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亞細胞定位：Cell membrane; Peripheral membrane protein. Cytoplasm.; [Isoform 4]: Endoplasmic reticulum.
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蛋白家族：Recoverin family
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組織特異性：Predominantly expressed in brain.
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數據庫鏈接：
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