KALRN Antibody

說明書

中文名稱：

KALRN兔多克隆抗體
貨號：

CSB-PA070197
規格：

￥1090
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

O60229
基因名：

KALRN
別名：

Duo antibody; FLJ16443 antibody; HAPIP antibody; Huntingtin associated protein interacting protein (duo) antibody; Huntingtin-associated protein-interacting protein antibody; Kalirin (isoform 2) antibody; Kalirin antibody; KALRN antibody; KALRN_HUMAN antibody; Protein Duo antibody; RhoGEF kinase antibody; Serine/threonine kinase with Dbl and pleckstrin homology domains antibody; Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain antibody; TRAD antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human Duo.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.
基因功能參考文獻：
1. SNPs of the KALRN gene are associated with intracranial atherosclerotic stenosis in the northern Chinese population. PMID: 30232674
2. Combination of polymorphisms in the NOD2, IL17RA, EPHA2 and KALRN genes could play a significant role in the development of sarcoidosis by maintaining a chronic pro-inflammatory status in macrophages PMID: 29554915
3. The GG genotype and G allele of SNP rs7620580 were associated with a risk for ischemic stroke with an adjusted OR of 3.195 and an OR of 1.446, respectively. Haplotype analysis revealed that A-T-G,G-T-A, and A-T-A haplotypes were associated with ischemic stroke. Our results provide evidence that kalirin gene variations were associated with ischemic stroke in the Chinese Han population. PMID: 28706949
4. DNA sequencing provided evidence linking KALRN to monogenic intellectual disability in two patients. PMID: 27421267
5. Data suggest protein levels of kalirin and CHD7 in circulating extracellular vesicles (EVs) as endothelial dysfunction markers to monitor vascular condition in hypertensive patients with albuminuria. PMID: 28152519
6. GG genotype and the G allele of the rs9289231 polymorphism of KALRN and the rs224766 polymorphism of ADIPOQ genes may be considered genetic risk factors for Iranian type 2 diabetic patients with coronary artery disease. PMID: 27218147
7. 4 KALRN gene SNPs were studied in Han ischemic stroke patients. rs11712619 seemed associated with lacunar stroke until risk factors were considered. re6438833 was significantly associated with ischemic and lacunar stroke. PMID: 25917671
8. consider the GG genotype and the G allele of rs9289231 polymorphism of KALRN to be genetic risk factors for CAD in an Iranian population, especially in early-stage atherosclerotic vascular disease PMID: 25316661
9. A sequence variant in human KALRN impairs protein ability to activate Rac1 and coincides with reduced cortical thickness. PMID: 25224588
10. The kalirin expression were reduced in Alzheimer disease with psychosis. PMID: 22429885
11. The age-at-onset of Huntington disease (HD) is not associated with eleven SNPs, including SNP rs10934657 in the kalirin gene in 680 European HD patients. PMID: 22720673
12. Neuronal guanine nucleotide exchange factor (GEF) kalirin is emerging as a key regulator of structural and functional plasticity at dendritic spines. PMID: 22194219
13. In both anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC), study found a reduction of Duo expression and PAK1 phosphorylation in schizophrenia. Cdc42 protein expression was decreased in ACC but not in DLPFC PMID: 22458949
14. Missense mutations in KALRN may be genetic risk factors for schizophrenia. PMID: 21041834
15. We found Kalirin-9 expression to be paradoxically increased in schizophrenia PMID: 22120753
16. KALRN gene variation is not associated with overall ischemic stroke PMID: 21664346
17. SNX1 and SNX2 interact with Kalirin-7. Overexpression of SNX1 or SNX2 and Kalirin-7 partially redistributes both SNXs to the plasma membrane, and results in RhoG-dependent lamellipodia formation. PMID: 20604901
18. Studies indicate that Kalirin-7 plays a key role in excitatory synapse formation and function. PMID: 20730383
19. Two SNPs in the KALRN gene region (rs17286604 and rs11712619)constitute risk factors for ischemic stroke. PMID: 20107840
20. we have identified multiple transcriptional start sites in rats and humans. These multiple transcriptional start sites result in full-length Kalirin transcripts possessing different 5' ends encoding proteins with differing amino termini PMID: 14742910
21. Kalirin GEF1 domain induces lamellipodia through activation of Pak, where Guanine nucleotide exchange factor (GEF) activity is not required. PMID: 15950621
22. Three SNPs from the kalirin (KALRN) gene are associated with early-onset coronary artery disease. PMID: 17357071
23. ARF6 recruits KALRN to the cell membrane facilitating Rac activation. PMID: 17640372
24. Our observation is the first to relate kalirin to Alzheimer's disease. Kalirin was consistently under-expressed in Alzheimer's disease hippocampus. PMID: 17851188
25. Kalirin-7 is an essential component of both shaft and spine excitatory synapses in hippocampal interneurons. PMID: 18199770
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相關疾病：

Coronary heart disease 5 (CHDS5)
亞細胞定位：

Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with the cytoskeleton.
蛋白家族：

Protein kinase superfamily, CAMK Ser/Thr protein kinase family
組織特異性：

Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle.
數據庫鏈接：

HGNC: 4814

OMIM: 604605

KEGG: hsa:8997

STRING: 9606.ENSP00000240874

UniGene: Hs.13281

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