JPH1 Antibody, Biotin conjugated
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中文名稱：JPH1兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA872553LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) JPH1 Polyclonal antibody
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Uniprot No.：
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基因名：JPH1
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別名：DKFZp762L0313 antibody; JP 1 antibody; JP-1 antibody; JP1 antibody; JPH 1 antibody; JPH1 antibody; JPH1_HUMAN antibody; Junctophilin 1 antibody; Junctophilin type 1 antibody; Junctophilin type1 antibody; Junctophilin-1 antibody; Junctophilin1 antibody; Mitsugumin 72 antibody; Mitsugumin72 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Junctophilin-1 protein (431-546AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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功能：Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes.
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基因功能參考文獻：
- This study suggests that genetic variants of JPH1 may modulate the effect of smoking on carotid plaque burden. PMID: 24954085
- This study demonstrates that both JP1 and JP2 in skeletal muscle undergo Ca2+-dependent proteolysis by endogenous proteases when the intracellular Ca2+ is raised within the physiological range for a sustained period PMID: 23148318
- JP1 and JP2 can facilitate the assembly of DHPR with other proteins of the excitation-contraction coupling machinery PMID: 22020936
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亞細胞定位：Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein.
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蛋白家族：Junctophilin family
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組織特異性：Abundantly expressed in skeletal muscle. Very low levels in heart.
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數據庫鏈接：
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