JAG2 Antibody

說明書

中文名稱：

JAG2兔多克隆抗體
貨號：

CSB-PA049990
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA049990(JAG2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA049990(JAG2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9Y219
基因名：

JAG2
別名：

JAG2 antibody; Protein jagged-2 antibody; Jagged2 antibody; hJ2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthetic peptide of Human JAG2
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:10000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development.
基因功能參考文獻：
1. In CL+/-P Malay patients, the prevalence of mutations in the Jagged2 gene was 12.5%. Three variants (g.19779C>T, g.19547G>A, and g.19712C>T) were identified in the Jagged2 gene among nonsyndromic CL+/-P and noncleft patients. Only g.19712C>T showed a significant association with nonsyndromic CL+/-P patients (P = .039). PMID: 26151095
2. these results show that the Notch signaling pathway in T cells is crucial for the induction of TH2-mediated allergic airway inflammation in an house dust mite -driven asthma model but that expression of Jagged 1 or Jagged 2 on DCs is not required PMID: 28111308
3. The authors present novel structures of human ligands Jagged2 and Delta-like4 and human Notch2, together with functional assays, which suggest that ligand-mediated coupling of membrane recognition and Notch binding is likely to be critical in establishing the optimal context for Notch signalling. PMID: 28572448
4. Immunohistochemistry showed a reverse correlation between MUC2 and Notch3 or Jagged1 (P = 0.033 and P = 0.005, respectively) and between MUC5AC and Jagged1 or Hes1 PMID: 22691042
5. Jagged-2 enhances immunomodulatory activity in adipose derived mesenchymal stem cells PMID: 26412454
6. Increased expression of JAG2, a target of miR-1280, is associated with high metastatic dissemination at diagnosis and a poor outcome in medulloblastoma. PMID: 25576913
7. Results show that tumor cell migration, invasion, and metastasis are dependent on JAGGED2 independently of NOTCH activation. PMID: 25351917
8. silencing prevents Notch2-driven osteoclast development and bone destruction in multiple myeloma PMID: 25257302
9. Although Jag1 shares a high degree of homology with Jag2 in the ectodomain region, BACE1 fails to cleave Jag2 effectively, indicating a selective cleavage of Jag1. PMID: 24907271
10. This study demonistrated that NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma. PMID: 24708907
11. Jagged2 expression status was closely correlated with important histopathologic characteristics (grades and stages) and the recurrence and metastasis of bladder urothelial carcinomas. PMID: 24228105
12. Notch-1 and Jagged-2 are not expressed in spastic colon segments, which may be associated with the pathogenesis of Hirschsprung disease. PMID: 22030773
13. JAG2-mediated Notch activation confers phenotypic and functional aspects of Langerhans cell histiocytosis to dendritic cells. PMID: 23074278
14. JAG2 is often expressed by CD138(+) primary cells. Our results indicate that spontaneous clonogenic growth of myeloma cells requires the expression of JAG2. PMID: 22341562
15. This study is the first illustration of Notch-1 and Jagged-2 expression in human tissues from non-cancerous disease. PMID: 21892607
16. hypoxia-induced Jagged2 activation in both tumor invasive front and normal bone stroma has a critical role in tumor progression and metastasis PMID: 21499308
17. The stromal cell-mediated antiapoptotic effect on B- ALL cells is mediated by Notch-3 and -4 or Jagged-1/-2 and DLL-1 in a synergistic manner. PMID: 21602525
18. hypoxic induction of JAG2 in tumor cells mediates a hypoxia-regulated cross-talk between tumor and endothelial cells. PMID: 21402725
19. we have investigated their influence on early human hematopoiesis and show that Jagged2 affects hematopoietic lineage decisions very similarly as Delta-like-1 and -4, but very different from Jagged1 PMID: 21372153
20. Expression of Notch3 and Jagged2 were highly correlated in tongue carcinoma tissues. PMID: 20819128
21. Notch signaling may participate in controlling cell differentiation and proliferation in normal bone and COF of the jaws. Notch signaling disorder may be a molecular incident in COF occurrence and development. PMID: 20040020
22. JAG2 is a direct Myc target and Jagged2 and Notch signaling participate in P493-6 lymphomagenesis. PMID: 20133585
23. expression required for spermatogenesis in humans and rats PMID: 11700865
24. JAG2 was found to be overexpressed in malignant plasma cells from MM patients; coculture assay demonstrated that JAG2 induced the secretion of IL-6, VEGF, and IGF-1 in stromal cells; JAG2 overexpression may be an early event in the pathogenesis of MM PMID: 15292061
25. The upregulation of Jagged2 expression on BMEC was observed upon TNF-alpha activation. Similarly,activation of endothelial cells in Tie2-tmTNF-alpha mice was characterized by increased expression of Jagged2. PMID: 18439488
26. Results indicate JAG2 may be involved in non-syndromic cleft lip with or without cleft palate etiology in different populations. PMID: 19049519
27. SMRT function restoration induces JAG2 down-regulation as well as multipe myeloma apoptosis. PMID: 19417136
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亞細胞定位：

Membrane; Single-pass type I membrane protein.
組織特異性：

Expressed in heart, placenta and skeletal muscle and to a lesser extent in pancreas. Very low expression in brain, lung, liver and kidney.
數據庫鏈接：

HGNC: 6189

OMIM: 602570

KEGG: hsa:3714

STRING: 9606.ENSP00000328169

UniGene: Hs.433445

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