ITSN2 Antibody

中文名稱：

ITSN2兔多克隆抗體
貨號：

CSB-PA873709LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Hela whole cell lysate, HEK293 whole cell lysate
All lanes: ITSN2 antibody at 4μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 194, 191, 142, 136 kDa
Observed band size: 194, 191, 142 kDa

Immunofluorescent analysis of HepG2 cells using CSB-PA873709LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ITSN2 Polyclonal antibody
Uniprot No.：

Q9NZM3
基因名：

ITSN2
別名：

ITSN2 antibody; KIAA1256 antibody; SH3D1B antibody; SWAP antibody; Intersectin-2 antibody; SH3 domain-containing protein 1B antibody; SH3P18 antibody; SH3P18-like WASP-associated protein antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Intersectin-2 protein (940-1209AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，ITSN2 Antibody (CSB-PA873709LA01HU)，的標記方式是Non-conjugated。對于ITSN2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA873709LB01HU	ITSN2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA873709LC01HU	ITSN2 Antibody, FITC conjugated
Biotin	CSB-PA873709LD01HU	ITSN2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes.
基因功能參考文獻：
1. These findings provide the basis for further functional investigations of the ITSN/CR16 complex that may play an important role in actin remodeling and cellular invasion. PMID: 28161632
2. ITSN2L interacts with RABEP1 and stimulates its degradation in regulation of endocytosis. PMID: 26633357
3. The ITSN2 interacts with Eps8 and stimulates the degradation of Eps8 proteins. PMID: 22449706
4. ITSN1 and ITSN2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins. PMID: 23936226
5. The sequence and structural alignment of ITSN-2L C2 domain with other members of C2 domain protein family indicate its vital cellular roles in membrane trafficking, the generation of lipid-second messengers and activation of GTPases. Moreover, our data show the possible roles of ITSN-2L C2 domain in regulating the activity of Cdc42. PMID: 23274495
6. These results highlight a role of Numb for dendritic spine development and synaptic functions with intersectin and EphB2. PMID: 16394100
7. ITSN2C may be specifically expressed in neurons hinting to a physiologic role in neuronal cell function. PMID: 17390067
8. We show that the PPLP motif of K15 protein selectively binds the SH3-C domain of an endocytic adaptor protein, Intersectin 2 (ITSN2). PMID: 17696407
9. ITSN-2L, a guanine nucleotide exchange factor for Cdc42, regulates different steps of caveola endocytosis in ECs by controlling the temporal and spatial actin polymerization and remodeling sub-adjacent to the plasma membrane. PMID: 19622753
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亞細胞定位：

Cytoplasm.
組織特異性：

Expressed in melanocytes. Ubiquitous. Isoform 1 is primarily expressed in adult heart and liver.
數據庫鏈接：

HGNC: 6184

OMIM: 604464

KEGG: hsa:50618

STRING: 9606.ENSP00000347244

UniGene: Hs.432562

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