ITPKC Antibody
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中文名稱：ITPKC兔多克隆抗體
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貨號：CSB-PA003041
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規格：￥1090
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圖片：
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Western Blot analysis of HT29 cells using InsP 3-kinase C Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：4 antibody; 5-trisphosphate 3-kinase C antibody; Inositol 1 antibody; inositol 1,4,5 trisphosphate 3 kinase C antibody; Inositol trisphosphate 3 kinase C antibody; Inositol-trisphosphate 3-kinase C antibody; InsP 3 kinase C antibody; InsP 3-kinase C antibody; IP3 3-kinase C antibody; IP3 3KC antibody; IP3K C antibody; IP3KC antibody; IP3KC_HUMAN antibody; Itpkc antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from the Internal region of Human InsP 3-kinase C.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:10000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate.
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基因功能參考文獻：
- This study identified several important polymorphisms in the ITPKC and SLC11A1 genes in Koreans. PMID: 29214786
- Genetic variants of ITPKC may have a potential association with HSCR (Hirschsprung disease) susceptibility and/or developmental diseases related to enteric nervous system development. PMID: 28664405
- this study shows that the KD-associated genetic polymorphism in inositol-triphosphate 3-kinase C (ITPKC) (rs28493229) has important functional consequences, governing ITPKC protein levels and thereby intracellular calcium, which in turn regulates NLRP3 expression and production of IL-1beta and IL-18. PMID: 27694492
- ITPKC polymorphisms are associated with Kawasaki disease. PMID: 24903211
- SNP rs7251246 in ITPKC is associated with the severity of Kawasaki disease PMID: 24621571
- Our results identify a novel polymorphism for renal function and highlight the importance of ITPKC as a key molecule to regulate calcium signaling. PMID: 24800221
- a combinatorial association between ITPKC (rs28493229) and CASP3 (rs113420705) was found in coronary artery lesion formation (P = 0.0227, OR: 3.06)in Taiwanese population PMID: 23894522
- functional studies demonstrated that PPP3CC positively influences the protein level of ITPKC, likely by inhibiting phosphorylation of ITPKC and consequently preventing ITPKC from ubiquitin-mediated protein degradation PMID: 23747857
- Functional single-nucleotide polymorphisms in ITPKC and CASP3 are associated with susceptibility to Kawasaki's disease (KD). PMID: 21987091
- the functional polymorphism rs28493229 in ITPKC significantly contributes to the risk of Kawasaki disease. PMID: 23065250
- The C allele of the ITPKC gene rs2290692 is linked to a significantly higher risk for KD in the Han Chinese population studied. PMID: 22361738
- ITPKC susceptibility in Kawasaki syndrome is related to its synergy with environmental triggers, such as thimerosal, which alter calcium homeostasis and promote oxidative stress. PMID: 22498790
- It was found the G/G genotype and G allele of the inositol 1,4,5-trisphosphate 3-kinase rs28493229 polymorphism may contribute to the risk of cervical squamous cell carcinoma in Taiwanese women. PMID: 22610085
- The study failed to prove any association between SNP rs28493229 of ITPKC gene and Kawasaki disease/coronary artery lesions in Chinese patients. PMID: 22161096
- results indicated that C-allele of ITPKC SNP rs28493229 is associated with the susceptibility and aneurysm formation in KD patients in a Taiwanese population PMID: 21533171
- Single nucleotide polymorphism rs28493229 in ITPKC contributes to Kawasaki disease susceptibility through induced hyperimmune function reflected in the BCG reactivation. PMID: 20805785
- A statistically significant association was not found between the ITPKC gene single-nucleotide polymorphism rs28493229 and Kawasaki disease or coronary artery lesions in Taiwanese children. PMID: 20045869
- results highlight the potential role of the three isoforms of InsP3 3-kinase as direct InsP3 metabolizing enzymes and direct regulators of Ca2+ responses to extracellular signals PMID: 12747803
- ITPKC acts as a negative regulator of T-cell activation through the Ca2+/NFAT signaling pathway, and the C allele may contribute to immune hyper-reactivity in Kawasaki disease. PMID: 18084290
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相關疾病：Kawasaki disease (KWD)
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亞細胞定位：Nucleus. Cytoplasm. Note=Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity.
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蛋白家族：Inositol phosphokinase (IPK) family
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組織特異性：Highly expressed in pancreas, skeletal muscle, liver, placenta and weakly in kidney and brain.
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數據庫鏈接：
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