ITGAE Antibody

說明書

中文名稱：

ITGAE兔多克隆抗體
貨號：

CSB-PA939663
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA939663(ITGAE Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA939663(ITGAE Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)

Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: LoVo cells, Primary antibody: CSB-PA939663(ITGAE Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P38570
基因名：

ITGAE
別名：

A530055J10 antibody; alpha-E1 antibody; alpha-M290 antibody; aM290 antibody; Antigen CD103 antibody; CD 103 antibody; CD103 antibody; CD103 antigen antibody; HML 1 antigen antibody; HML-1 antigen antibody; HML1 antigen antibody; Human mucosal lymphocyte antigen 1 antibody; Human mucosal lymphocyte antigen 1, alpha subunit antibody; Huminae antibody; Integrin alpha E antibody; Integrin alpha E heavy chain antibody; Integrin alpha E light chain antibody; Integrin alpha E, epithelial-associated antibody; Integrin alpha E1 antibody; Integrin alpha IEL antibody; Integrin alpha M290 antibody; Integrin alpha-E heavy chain antibody; Integrin alpha-IEL antibody; Integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1, alpha polypeptide) antibody; Integrin, alpha E antibody; ITAE_HUMAN antibody; Itgae antibody; MGC141996 antibody; MGC183601 antibody; Mucosal lymphocyte 1 antigen antibody; Mucosal lymphocyte antigen 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Fusion protein of Human ITGAE
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.
基因功能參考文獻：
1. Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors. PMID: 30006565
2. Pxn binding to the CD103 cytoplasmic tail triggers alphaEbeta7 integrin outside-in signaling that promotes CD8(+) T-cell migratory behavior and effector functions. PMID: 29021139
3. The CD103+CD4+/CD4+ ratio does not accurately discriminate between sarcoidosis and other causes of lymphocytic alveolitis, neither alone nor in combination with the CD4+/CD8+ ratio, and is not a powerful marker for the diagnosis of sarcoidosis. PMID: 27230039
4. CD103 expression in human dendritic cells is regulated differentially by retinoic acid and Toll-like receptor ligands. PMID: 28087652
5. detected CD103 tumor cells in 41% (16/39) of lymph node-involved adult T-cell leukemia/lymphoma PMID: 26813744
6. Levels of GZMA and ITGAE mRNAs in colon tissues can identify patients with UC who are most likely to benefit from etrolizumab; expression levels decrease with etrolizumab administration in biomarker(high) patients. PMID: 26522261
7. PD-1(+)CD103(+) CD8 TIL might regain functional antitumor activity, an effect that potentially could be augmented by immune modulation. PMID: 25957117
8. This report highlights the diagnostic difficulties and the need of consensus in categorizing clonal CD103(+) lymphocytosis in patients with refractory celiac disease. PMID: 25637255
9. Cell-sorting experiments demonstrated that IDO1 expression is found in a subset of CD1a(+)CD14(-)langerin(+) cells, expressing CD103 PMID: 25584868
10. Report CD103 expression occurs most frequently in gastrointestinal T-cell lymphomas. PMID: 25025448
11. Tumor-infiltrating lymphocytes expressing the tissue resident memory marker CD103 are associated with increased survival in high-grade serous ovarian cancer. PMID: 24190978
12. Using a human CTL system model based on a CD8(+)/CD103(-) T cell clone specific of a lung tumor-associated Ag, we demonstrated that the transcription factors Smad2/3 and NFAT-1 are two critical regulators of this process. PMID: 24477908
13. Memory CD103+ CD8 T cells that persist within the brain after an acute infection with vesicular stomatitis virus are bona fide tissue resident memory cells. PMID: 22922816
14. Lymphoid tissue (LT)-resident CD8alpha-positive dendritic cells (DCs) and non(LT)-derived CD103-positive DCs express transgenic XCR1 and are characterized by a unique transcriptional fingerprint, irrespective of their tissue of origin. PMID: 21948982
15. These findings support the usefulness of CD123 and CD103 to aid in the differential diagnosis of B-cell lymphoproliferative disorders PMID: 21917686
16. Studies indicate that the mechanisms that regulate the retention of tissue-resident memory T cells include TGF-beta-mediated induction of CD103 and downregulation of CCR7. PMID: 21739671
17. results show that binding of the human alphaE I domain to oral and skin keratinocytes is independent of E-cadherin PMID: 20875079
18. has a role in mucosal immunity and graft rejection PMID: 12370249
19. Involvement of the adhesive ligand pair CD103-E-cadherin in human thymocyte cell proliferation PMID: 12414996
20. Differential up-regulation of CD103 expression on lamina propria lymphocytes in Crohn's disease may indicate differential humoral or cellular regulation in inducing CD103 molecules on lymphocytes in patients with this disease PMID: 14532999
21. CD103 promotes destruction of renal allografts by CD8 T cells PMID: 15196058
22. Integrin/activation marker CD103 (alphaEbeta7) is expressed on Epstein-Barr virus-specific tonsil-resident (but not peripheral blood mononuclear leukocyte-derived) cytotoxic T lymphocytes. PMID: 16177076
23. CD103 expression on dendritic cells influences the balance between effector and regulatory T cell activity in the intestine. PMID: 16216886
24. human alloantigen-induced CD103+ CD8+ T cells possess functional features of regulatory T cells PMID: 16920912
25. CD8+/CD103+ tumor-reactive T lymphocytes infiltrating epithelial tumors most likely play a major role in antitumor cytotoxic response through alphaEbeta7-E-cadherin interactions. PMID: 17325197
26. An investigation to evaluate the diagnostic value of relative number of CD103 expressing CD4(+) T-lymphocytes in the BAL fluid of patients with a variety of interstitial lung diseases, including pulmonary sarcoidosis, is reported. PMID: 18182176
27. integrin alpha(E)(CD103)beta(7) is not only involved in epithelial retention, but also in shaping and proper intraepithelial morphogenesis of some leukocytes. PMID: 18492951
28. Phenotypic analysis of peripheral blood and decidual CD8+ T cells showed the presence of activated CD8+ T cells as well as a population of CD8+CD103+ T cells in decidual tissue PMID: 19150377
29. A higher proportion of CD103+CD4+ T cells and ITGAE -1088 AA genotype might be associated with fibrosis formation in pulmonary sarcoidosis. PMID: 19604725
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亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Integrin alpha chain family
組織特異性：

Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.
數據庫鏈接：

HGNC: 6147

OMIM: 604682

KEGG: hsa:3682

STRING: 9606.ENSP00000263087

UniGene: Hs.513867

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