IP6K2 Antibody
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中文名稱：IP6K2兔多克隆抗體
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貨號：CSB-PA109004
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規格：￥2024
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圖片：
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Western blot analysis of extracts from HUVEC cells, Jurkat cells and COLO cells, using IP6K2 antibody. -
Immunofluorescence analysis of COS-7 cells, using IP6K2 antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) IP6K2 Polyclonal antibody
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Uniprot No.：
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基因名：
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from internal of Human IP6K2.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IF
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 IF 1:100-1:500 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5).
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基因功能參考文獻：
- An alpha-helical pair and a rare, two-turn 310 helix, that together form a substrate-binding pocket of IP6K2. PMID: 24956979
- FGF2-signaling involves the inositol polyphosphate cascade, including inositol hexakisphosphate kinase (IP6K), and demonstrate that IP6K1,2 regulates Runx2 and osteoblast gene expression. PMID: 23322705
- Genetic polymorphisms in IP6K2 gene is associated with autoimmune disease. PMID: 22446964
- Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2. PMID: 21262846
- Gene disruption of IP6K2 in colorectal cancer cells selectively impairs p53-mediated apoptosis, instead favoring cell-cycle arrest. IP6K2 acts by binding directly to p53 and decreasing expression of proarrest gene targets PMID: 21078964
- IHPK2 over expression enhances sensitivity of ovarian carcinoma cells to radiation, IFN-beta, caspase 8 and DR4 PMID: 11896621
- InsP6K2 is a physiologic mediator of cell death PMID: 15533939
- IHPK2-TRAF2 binding leads to attenuation of TAK1- and NF-kappaB-mediated signaling and is partially responsible for the apoptotic activity of IHPK2. PMID: 17379600
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亞細胞定位：Nucleus.
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蛋白家族：Inositol phosphokinase (IPK) family
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數據庫鏈接：
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