INPP5K Antibody
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中文名稱：INPP5K兔多克隆抗體
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貨號：CSB-PA866277ESR1HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA866277ESR1HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) INPP5K Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：43 kDa form skeletal muscle and kidney enriched inositol phosphatase antibody; Inositol polyphosphate 5-phosphatase K antibody; INP5K_HUMAN antibody; INPP5K antibody; muscle and kidney-enriched inositol phosphatase antibody; PPS antibody; skeletal muscle and kidney enriched inositol phosphatase antibody; Skeletal muscle and kidney-enriched inositol phosphatase antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Inositol polyphosphate 5-phosphatase K protein (149-448AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle.
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基因功能參考文獻：
- the distribution of genotype frequency exhibited no significant differences between the Parkinson's disease and control groups (P > 0.025) in INPP5K rs1109303 (P = 0.048, OR = 0.806, 95%CI = 0.650 - 0.998). PMID: 29607885
- In individuals exhibiting congenital muscular dystrophy, early-onset cataracts, and mild intellectual disability but normal cranial magnetic resonance imaging, we identified bi-allelic mutations in INPP5K, encoding inositol polyphosphate-5-phosphatase K. PMID: 28190456
- Mutations in INPP5K cause a congenital muscular dystrophy syndrome with short stature, cataracts, and intellectual disability. PMID: 28190459
- These findings suggest a model by which GRP78 regulates intracellular localization of SKIP and how SKIP binds to Pak1 on insulin stimulation. PMID: 26940976
- Study reveals that SKIP is a significant regulator of glioblastoma cell migration and that increased expression of SKIP may confer a survival advantage. PMID: 25241900
- SKIP controls the IGF-II-PI 3-kinase-Akt-mTOR auto-regulation loop during myogenesis. PMID: 22815484
- Specific suppression of insulin signaling is achieved via the spatiotemporal regulation of SKIP through the scaffolding function of Pak1. PMID: 22751929
- identification of novel domain that mediates membrane ruffle localization PMID: 12536145
- The authors report that HBV core protein interacts with a cellular SKIP (skeletal muscle and kidney enriched inositol phosphatase) protein, an endoplasmic reticulum-located phosphoinositide 5-phosphatase, both in vivo and in vitro. PMID: 18774950
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相關疾病：Muscular dystrophy, congenital, with cataracts and intellectual disability (MDCCAID)
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亞細胞定位：Endoplasmic reticulum. Cytoplasm.
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蛋白家族：Inositol 1,4,5-trisphosphate 5-phosphatase type II family
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組織特異性：Ubiquitously expressed with highest levels in skeletal muscle, heart and kidney.
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數據庫鏈接：
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