INPP4A Antibody

中文名稱：

INPP4A兔多克隆抗體
貨號(hào)：

CSB-PA853479ESR1HU
規(guī)格：

￥440
圖片：
Western blot
All lanes: INPP4A antibody at 8.79 μg/ml + Mouse brain tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 110, 106, 108 kDa
Observed band size: 110, 48 kDa

Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA853479ESR1HU at dilution of 1:100
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
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靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) INPP4A Polyclonal antibody
Uniprot No.：

Q96PE3
基因名：

INPP4A
別名：

107kDa antibody; 4-bisphosphate 4-phosphatase antibody; 9630012D15 antibody; D130048C09Rik antibody; Inositol polyphosphate 4 phosphatase type I 107kDa antibody; Inositol polyphosphate 4 phosphatase type I antibody; Inositol polyphosphate 4-phosphatase type I antibody; INP4A_HUMAN antibody; INPP4 antibody; Inpp4a antibody; OTTHUMP00000203138 antibody; OTTHUMP00000203139 antibody; OTTHUMP00000203141 antibody; OTTHUMP00000225217 antibody; R74740 antibody; TVAS1 antibody; Type I inositol 3 4 bisphosphate 4 phosphatase antibody; Type I inositol 3,4 bisphosphate 4 phosphatase antibody; Type I inositol-3 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human, Mouse
免疫原：

Recombinant Human Type I inositol 3,4-bisphosphate 4-phosphatase protein (1-250AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
克隆類(lèi)型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current.; Displays no 4-phosphatase activity for PtdIns(3,4)P2, Ins(3,4)P2, or Ins(1,3,4)P3.
基因功能參考文獻(xiàn)：
1. Our findings indicate that upregulation of miR-935 may promote pancreatic cancer cell proliferation and migration and inhibit cell apoptosis by targeting INPP4A. PMID: 27733216
2. INPP4A could possibly serve as a candidate gene for alterations associated with asbestos exposure. PMID: 26463840
3. Data adds a new etiology to the spectrum of hindbrain malformations in human, and when presented with myoclonic epilepsy may lead to the clinical suspicion of INPP4A defect. PMID: 25338135
4. INPP4A represents the first signalling protein with a function in neurons to suppress excitotoxic cell death PMID: 20463662
5. in quiescent cells, the 4-phosphatase colocalized with early and recycling endosomes PMID: 15716355
6. The +110832A/G (Thr/Ala) variant of INPP4A was significantly associated with asthma in an Indian population. PMID: 18187694
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亞細(xì)胞定位：

Early endosome membrane. Recycling endosome membrane. Cell membrane. Nucleus. Cytoplasm. Cell junction, synapse, postsynaptic density.
蛋白家族：

Inositol 3,4-bisphosphate 4-phosphatase family
組織特異性：

Isoform 1 is expressed in the platelets, MEG-01 megakaryocytes and Jurkat T-cells. Isoform 2 is expressed in the brain.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 6074

OMIM: 600916

KEGG: hsa:3631

STRING: 9606.ENSP00000074304

UniGene: Hs.469386

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